PTGR1 antibody (N-Term)

Catalog No. ABIN2785929

Product Details anti-PTGR1 Antibody

Target: PTGR1 (Prostaglandin Reductase 1 (PTGR1))

Binding Specificity: N-Term

Reactivity: Human, Rat, Rabbit, Horse, Cow, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTGR1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: VRTKTWTLKK HFVGYPTNSD FELKTSELPP LKNGEVLLEA LFLTVDPYMR

Predicted Reactivity: Cow: 93%, Guinea Pig: 83%, Horse: 83%, Human: 93%, Rabbit: 83%, Rat: 79%

Characteristics: This is a rabbit polyclonal antibody against LTB4DH. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human LTB4DH

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 329 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-PTGR1 antibody (ABIN2785929)

Vitturi, Chen, Woodcock, Salvatore, Bonacci, Koenitzer, Stewart, Wakabayashi, Kensler, Freeman, Schopfer: "Modulation of nitro-fatty acid signaling: prostaglandin reductase-1 is a nitroalkene reductase." in: The Journal of biological chemistry, Vol. 288, Issue 35, pp. 25626-37, (2013) (PubMed).

Target Details for PTGR1

Target: PTGR1 (Prostaglandin Reductase 1 (PTGR1))

Alternative Name: LTB4DH (PTGR1 Products)

Synonyms: LTB4DH antibody, PGR1 antibody, ZADH3 antibody, 2510002C21Rik antibody, Ltb4dh antibody, Dig1 antibody, ltb4dh antibody, wu:fj35e05 antibody, zgc:101689 antibody, PTGR1 antibody, prostaglandin reductase 1 antibody, PTGR1 antibody, Ptgr1 antibody, ptgr1 antibody

Background: LTB4DH functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. It has no activity towards PGE1, PGE2 and PGE2-alpha. LTB4DH catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4.
Alias Symbols: MGC34943, PGR1, ZADH3, LTB4DH
Protein Interaction Partner: PRDX5, PEBP1, ATP6V1A, UBC,
Protein Size: 329

Molecular Weight: 36 kDa

Gene ID: 22949

NCBI Accession: NM_012212, NP_036344

UniProt: A8K0N2