ANGPTL2 antibody (N-Term)

Catalog No. ABIN2785913

Product Details anti-ANGPTL2 Antibody

Target: ANGPTL2 (Angiopoietin-Like 2 (ANGPTL2))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ANGPTL2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: NSKEPEVLLE NRVHKQELEL LNNELLKQKR QIETLQQLVE VDGGIVSEVK

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against ANGPTL2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ANGPTL2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 493 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-ANGPTL2 antibody (ABIN2785913)

Doblinger, Höcherl, Mederle, Kattler, Walter, Hansen, Jensen, Castrop: "Angiotensin AT1 receptor-associated protein Arap1 in the kidney vasculature is suppressed by angiotensin II." in: American journal of physiology. Renal physiology, Vol. 302, Issue 10, pp. F1313-24, (2012) (PubMed).

Sun, Zheng, Chen, Zeng, Liu, Li: "Enhanced expression of ANGPTL2 in the microvascular lesions of diabetic glomerulopathy." in: Nephron. Experimental nephrology, Vol. 105, Issue 4, pp. e117-23, (2007) (PubMed).

Target Details for ANGPTL2

Target: ANGPTL2 (Angiopoietin-Like 2 (ANGPTL2))

Alternative Name: ANGPTL2 (ANGPTL2 Products)

Background: Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. ANGPTL2 is a secreted glycoprotein with homology to the angiopoietins and may exert a function on endothelial cells through autocrine or paracrine action.Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. ANGPTL2 protein is a secreted glycoprotein with homology to the angiopoietins and may exert a function on endothelial cells through autocrine or paracrine action. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-127 AL598400.1 2-128 128-451 AL598400.1 129-452 452-2289 BC012368.1 325-2162 2290-3572 AK074726.1 1294-2576
Alias Symbols: ARP2, HARP, MGC8889
Protein Size: 493

Molecular Weight: 57 kDa

Gene ID: 23452

NCBI Accession: NM_012098, NP_036230

UniProt: Q9UKU9