Peroxiredoxin 5 antibody (Middle Region)

Catalog No. ABIN2785911

Product Details anti-Peroxiredoxin 5 Antibody

Target: Peroxiredoxin 5 (PRDX5)

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Goat, Dog, Guinea Pig, Horse, Sheep, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Peroxiredoxin 5 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: TDLLLDDSLV SIFGNRRLKR FSMVVQDGIV KALNVEPDGT GLTCSLAPNI

Predicted Reactivity: Dog: 86%, Goat: 79%, Guinea Pig: 79%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 93%, Rat: 93%, Sheep: 79%

Characteristics: This is a rabbit polyclonal antibody against PRDX5. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PRDX5

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 125 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-Peroxiredoxin 5 antibody (ABIN2785911)

Trujillo, Clippe, Manta, Ferrer-Sueta, Smeets, Declercq, Knoops, Radi: "Pre-steady state kinetic characterization of human peroxiredoxin 5: taking advantage of Trp84 fluorescence increase upon oxidation." in: Archives of biochemistry and biophysics, Vol. 467, Issue 1, pp. 95-106, (2007) (PubMed).

Target Details for Peroxiredoxin 5

Target: Peroxiredoxin 5 (PRDX5)

Alternative Name: PRDX5 (PRDX5 Products)

Background: PRDX5 is a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in different tissues under normal conditions and during inflammatory processes. This protein interacts with peroxisome receptor 1. The crystal structure of this protein in its reduced form has been resolved to 1.5 angstrom resolution. This gene uses alternate in-frame translation initiation sites to generate mitochondrial or peroxisomal/cytoplasmic forms.This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in different tissues under normal conditions and during inflammatory processes. This protein interacts with peroxisome receptor 1. The crystal structure of this protein in its reduced form has been resolved to 1.5 angstrom resolution. This gene uses alternate in-frame translation initiation sites to generate mitochondrial or peroxisomal/cytoplasmic forms. Three transcript variants encoding distinct isoforms have been identified for this gene.
Alias Symbols: ACR1, AOEB166, B166, MGC117264, MGC142283, MGC142285, PLP, PMP20, PRDX6, PRXV, SBBI10
Protein Interaction Partner: UBC, MDM2, WWOX, ATF2, PEX5, TOMM40, PRDX6, STAM, SUMO1, UBE2B, UBE2A, PRDX2, VAMP2, SOD1, RPS12, RAD23B, PTMS, PRDX1, MDH1, IGBP1, APP, ZFYVE19, PSRC1, GINS4, UBAP2, PTPN23, PTGR1, PARK7, IFT27, SEC24A, SSSCA1, ICT1, BABAM1, CCDC90B,
Protein Size: 125

Molecular Weight: 14 kDa

Gene ID: 25824

NCBI Accession: NM_181652, NP_857635

UniProt: B7ZVW3

Pathways: Cell RedoxHomeostasis