INHBA antibody (N-Term)

Catalog No. ABIN2785821

Product Details anti-INHBA Antibody

Target: INHBA (Inhibin, beta A (INHBA))

Binding Specificity: N-Term

Reactivity: Human, Rat, Mouse, Cow, Pig, Horse, Sheep, Goat, Rabbit, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This INHBA antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: CPSCALAALP KDVPNSQPEM VEAVKKHILN MLHLKKRPDV TQPVPKAALL

Predicted Reactivity: Cow: 100%, Dog: 93%, Goat: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%, Sheep: 100%

Characteristics: This is a rabbit polyclonal antibody against INHBA. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human INHBA

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 426 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-INHBA antibody (ABIN2785821)

Ndiaye, Castonguay, Benoit, Silversides, Lussier: "Differential regulation of Janus kinase 3 (JAK3) in bovine preovulatory follicles and identification of JAK3 interacting proteins in granulosa cells." in: Journal of ovarian research, Vol. 9, Issue 1, pp. 71, (2016) (PubMed).

Target Details for INHBA

Target: INHBA (Inhibin, beta A (INHBA))

Alternative Name: INHBA (INHBA Products)

Synonyms: EDF antibody, FRP antibody, actba antibody, inhba antibody, inhbaa-001 antibody, edf antibody, frp antibody, INHB antibody, inhbal antibody, zgc:158348 antibody, inhibin beta A subunit antibody, inhibin beta-A antibody, inhibin, beta Aa antibody, inhibin beta A antibody, inhibin, beta Ab antibody, INHBA antibody, Inhba antibody, inhbaa antibody, inhba antibody, inhbab antibody

Background: The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. Finally, it has been shown that the beta A subunit mRNA is identical to the erythroid differentiation factor subunit mRNA and that only one gene for this mRNA exists in the human genome.
Alias Symbols: EDF, FRP
Protein Interaction Partner: ACVRL1, ACVR2B, ACVR2A, ACVR1, FST, IGSF1, CHRDL2, FSTL3, IGFBP7, ACVR1B, INHBC, TGFBR3, INHBB, INHA, INHBA, ENG,
Protein Size: 426

Molecular Weight: 44 kDa

Gene ID: 3624

NCBI Accession: NM_002192, NP_002183

UniProt: P08476

Pathways: Hormone Transport, Peptide Hormone Metabolism, Hormone Activity, Negative Regulation of Hormone Secretion, Autophagy