EPS15 antibody (C-Term)

Catalog No. ABIN2785791

Product Details anti-EPS15 Antibody

Target: EPS15 (Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Cow, Horse, Pig, Dog, Guinea Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EPS15 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: LDSPDPFKLN DPFQPFPGND SPKEKDPEIF CDPFTSATTT TNKEADPSNF

Predicted Reactivity: Cow: 100%, Dog: 93%, Guinea Pig: 79%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against EPS15. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human EPS15

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 896 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for EPS15

Target: EPS15 (Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15))

Alternative Name: EPS15 (EPS15 Products)

Background: EPS15 is a protein that is part of the EGFR pathway. The protein is present at clatherin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemias.This gene encodes a protein that is part of the EGFR pathway. The protein is present at clatherin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemias. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: AF-1P, AF1P, MLLT5
Protein Interaction Partner: TRIM63, UBC, GJA1, EPHA2, CORO7, RNF11, RABL6, OPTN, LAPTM5, VCAM1, ITGA4, FN1, Fcho2, Dab2, STON2, EPN1, AGFG1, EPS15, CRKL, CRK, AP2S1, AP2M1, AP2B1, AP1B1, AP2A2, AP2A1, ACTB, ABL1, NECAP1, SPG20, VPRBP, KRT75, IQGAP1, KRT36, KRT37, KRT38, CCT3, TRAF2,
Protein Size: 896

Molecular Weight: 99 kDa

Gene ID: 2060

NCBI Accession: NM_001981, NP_001972

UniProt: P42566

Pathways: EGFR Signaling Pathway, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, EGFR Downregulation