IMPDH2 antibody (N-Term)
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- Target See all IMPDH2 Antibodies
- IMPDH2 (IMP (Inosine 5'-Monophosphate) Dehydrogenase 2 (IMPDH2))
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Binding Specificity
- N-Term
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Reactivity
- Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio)
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This IMPDH2 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Sequence
- MADYLISGGT SYVPDDGLTA QQLFNCGDGL TYNDFLILPG YIDFTADQVD
- Predicted Reactivity
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%
- Characteristics
- This is a rabbit polyclonal antibody against IMPDH2. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human IMPDH2
- Top Product
- Discover our top product IMPDH2 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 514 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- IMPDH2 (IMP (Inosine 5'-Monophosphate) Dehydrogenase 2 (IMPDH2))
- Alternative Name
- IMPDH2 (IMPDH2 Products)
- Synonyms
- imp2 antibody, impd2 antibody, impdh-ii antibody, impdh2 antibody, IMPD2 antibody, IMPDH-II antibody, IMPD 2 antibody, IMPDH 2 antibody, cb635 antibody, wu:fb64g02 antibody, wu:fc43f09 antibody, IMPD antibody, inosine monophosphate dehydrogenase 2 antibody, IMP (inosine 5'-monophosphate) dehydrogenase 2 antibody, inosine 5'-phosphate dehydrogenase 2 antibody, IMPDH2 antibody, impdh2.S antibody, impdh2 antibody, Impdh2 antibody
- Background
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IMPDH2 is the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. It catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. IMPDH2 is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.
Alias Symbols: IMPD2, IMPDH-II
Protein Interaction Partner: RSG1, APIP, HUWE1, UBC, IMPDH2, CDK2, RPA1, RPA3, RPA2, PRKAR2A, IMPDH1, EIF2S3, PARK2, MAPK10, SOX2, NPM1, PEX14, FN1, RPLP0P6, RPS6, RPL15, FOLR1, FBXO6, GRB2, UBQLN4, PIAS4, COPS5, COPS6, CUL3, YWHAZ, FBXO25, SIRT7, HDAC5, MME, SUMO4, AKT1, IKBKE, ATG5
Protein Size: 514 - Molecular Weight
- 56 kDa
- Gene ID
- 3615
- NCBI Accession
- NM_000884, NP_000875
- UniProt
- P12268
- Pathways
- Ribonucleoside Biosynthetic Process, SARS-CoV-2 Protein Interactome
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