IL1A antibody (N-Term)
-
- Target See all IL1A Antibodies
- IL1A (Interleukin 1 alpha (IL1A))
-
Binding Specificity
- N-Term
-
Reactivity
- Human, Mouse, Rat, Horse, Goat, Dog, Cow, Sheep
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- This IL1A antibody is un-conjugated
-
Application
- Western Blotting (WB)
- Sequence
- VSYGPLHEGC MDQSVSLSIS ETSKTSKLTF KESMVVVATN GKVLKKRRLS
- Predicted Reactivity
- Cow: 92%, Dog: 85%, Goat: 85%, Horse: 93%, Human: 100%, Mouse: 79%, Rat: 79%, Sheep: 85%
- Characteristics
- This is a rabbit polyclonal antibody against IL1A. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human IL1A
- Top Product
- Discover our top product IL1A Primary Antibody
-
-
- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
-
Antigen size: 271 AA
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
-
-
Shigella flexneri T3SS effector IpaH4.5 modulates the host inflammatory response via interaction with NF-?B p65 protein." in: Cellular microbiology, Vol. 15, Issue 3, pp. 474-85, (2013) (PubMed).
: "Intracellular interleukin-1 receptor 2 binding prevents cleavage and activity of interleukin-1?, controlling necrosis-induced sterile inflammation." in: Immunity, Vol. 38, Issue 2, pp. 285-95, (2013) (PubMed).
: "
-
Shigella flexneri T3SS effector IpaH4.5 modulates the host inflammatory response via interaction with NF-?B p65 protein." in: Cellular microbiology, Vol. 15, Issue 3, pp. 474-85, (2013) (PubMed).
-
- Target
- IL1A (Interleukin 1 alpha (IL1A))
- Alternative Name
- IL1A (IL1A Products)
- Synonyms
- IL-1A antibody, IL1 antibody, IL1-ALPHA antibody, IL1F1 antibody, IL-6 antibody, Il-1a antibody, IL-1 alpha antibody, IL-1alpha antibody, L1A antibody, interleukin 1 alpha antibody, interleukin 6 antibody, IL1A antibody, IL6 antibody, Il1a antibody
- Background
-
The IL1A protein is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. The gene encoding IL1A and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease.The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: IL-1A, IL1, IL1-ALPHA, IL1F1
Protein Interaction Partner: HFI1, AHC1, GCN5, SPT7, ADA2, NGG1, SPT8, HAX1, NFKBIE, IL1RAP, NDN, S100A13, IL1R2, IL1R1, IL1A, CAPN1,
Protein Size: 271 - Molecular Weight
- 18 kDa
- Gene ID
- 3552
- NCBI Accession
- NM_000575, NP_000566
- UniProt
- P01583
- Pathways
- NF-kappaB Signaling, Autophagy, Cancer Immune Checkpoints
-