Actl7b antibody (Middle Region)

Catalog No. ABIN2785506

Product Details anti-Actl7b Antibody

Target: Actl7b (Actin-Like 7b (Actl7b))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Dog, Cow

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Actl7b antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: KLITIGQERF RCSEMLFQPS LAGSTQPGLP ELTAACLGRC QDTGFKEEMA

Predicted Reactivity: Cow: 77%, Dog: 83%, Human: 100%, Mouse: 85%, Rat: 92%

Characteristics: This is a rabbit polyclonal antibody against ACTL7B. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ACTL7B

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 416 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Actl7b

Target: Actl7b (Actin-Like 7b (Actl7b))

Alternative Name: ACTL7B (Actl7b Products)

Background: ACTL7B is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. Based on mutational analysis of the ACTL7B gene in patients with this disorder, it was concluded that it is unlikely to be involved in the pathogenesis of dysautonomia. Unlike ACTL7A, the ACTL7B gene is expressed predominantly in the testis, however, its exact function is not known.The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene (ACTL7B), and related gene, ACTL7A, are intronless, and are located approximately 4 kb apart in a head-to-head orientation within the familial dysautonomia candidate region on 9q31. Based on mutational analysis of the ACTL7B gene in patients with this disorder, it was concluded that it is unlikely to be involved in the pathogenesis of dysautonomia. Unlike ACTL7A, the ACTL7B gene is expressed predominantly in the testis, however, its exact function is not known.
Alias Symbols: Tact1
Protein Interaction Partner: APP,
Protein Size: 416

Molecular Weight: 46 kDa

Gene ID: 10880

NCBI Accession: NM_006686, NP_006677

UniProt: Q9Y614