CCDC50 antibody (Middle Region)

Catalog No. ABIN2785358

Product Details anti-CCDC50 Antibody

Target: CCDC50 (Coiled-Coil Domain Containing 50 (CCDC50))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Rabbit, Horse, Cow, Dog, Guinea Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CCDC50 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: GMKPRVMKEA VSTPSRMAHR DQEWYDAEIA RKLQEEELLA TQVDMRAAQV

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 77%

Characteristics: This is a rabbit polyclonal antibody against CCDC50. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CCDC50

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 482 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CCDC50

Target: CCDC50 (Coiled-Coil Domain Containing 50 (CCDC50))

Alternative Name: CCDC50 (CCDC50 Products)

Background: CCDC50 is a soluble, cytoplasmic, tyrosine-phosphorylated protein with multiple ubiquitin-interacting domains. Mutations in this gene cause nonsyndromic, postlingual, progressive sensorineural DFNA44 hearing loss. In mouse, the protein is expressed in the inner ear during development and postnatal maturation and associates with microtubule-based structures. This protein may also function as a negative regulator of NF-kB signaling and as an effector of epidermal growth factor (EGF)-mediated cell signaling.
Alias Symbols: C3orf6, DFNA44, YMER
Protein Interaction Partner: UBC, SH3RF2, RIPK1, TNFAIP3, EGFR, RPS3A,
Protein Size: 482

Molecular Weight: 56 kDa

Gene ID: 152137

NCBI Accession: NM_178335, NP_848018

UniProt: Q8IVM0