ZCCHC12 antibody (N-Term)

Catalog No. ABIN2785325

Product Details anti-ZCCHC12 Antibody

Target: ZCCHC12 (Zinc Finger, CCHC Domain Containing 12 (ZCCHC12))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rabbit, Rat, Cow, Dog, Guinea Pig, Horse, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZCCHC12 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: AREVMRVLQA TNPNLSVADF LRAMKLVFGE SESSVTAHGK FFNTLQAQGE

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 100%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against ZCCHC12. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ZCCHC12

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 402 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ZCCHC12

Target: ZCCHC12 (Zinc Finger, CCHC Domain Containing 12 (ZCCHC12))

Alternative Name: ZCCHC12 (ZCCHC12 Products)

Synonyms: PNMA7A antibody, SIZN antibody, SIZN1 antibody, 2810028A01Rik antibody, AV136720 antibody, Sizn1 antibody, zinc finger CCHC-type containing 12 antibody, sterile alpha motif domain containing 12 antibody, zinc finger, CCHC domain containing 12 antibody, ZCCHC12 antibody, samd12 antibody, Zcchc12 antibody

Background: ZCCHC12 contains 1 CCHC-type zinc finger. ZCCHC12 is the transcriptional coactivator in the bone morphogenetic protein (BMP)-signaling pathway. It positively modulates BMP signaling by interacting with SMAD1 and associating with CBP in the transcription complex. It contributes to the BMP-induced enhancement of cholinergic-neuron-specific gene expression.
Alias Symbols: FLJ16123, SIZN, SIZN1, PNMA7A
Protein Interaction Partner: PNMA1, SUMO1, TFCP2, MAGEA11, SUMO2, APP, SMAD1, CREBBP, UBC, APPBP2,
Protein Size: 402

Molecular Weight: 45 kDa

Gene ID: 170261

NCBI Accession: NM_173798, NP_776159

UniProt: Q6PEW1