TMPRSS6 antibody (N-Term)
-
- Target See all TMPRSS6 Antibodies
- TMPRSS6 (Transmembrane Protease, serine 6 (TMPRSS6))
-
Binding Specificity
- N-Term
-
Reactivity
- Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- This TMPRSS6 antibody is un-conjugated
-
Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Sequence
- LLWYFLGYKA EVMVSQVYSG SLRVLNRHFS QDLTRRESSA FRSETAKAQK
- Predicted Reactivity
- Cow: 100%, Dog: 93%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rat: 100%
- Characteristics
- This is a rabbit polyclonal antibody against TMPRSS6. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human TMPRSS6
- Top Product
- Discover our top product TMPRSS6 Primary Antibody
-
-
- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
-
Antigen size: 811 AA
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
-
- Target
- TMPRSS6 (Transmembrane Protease, serine 6 (TMPRSS6))
- Alternative Name
- TMPRSS6 (TMPRSS6 Products)
- Synonyms
- IRIDA antibody, 1300008A22Rik antibody, transmembrane protease, serine 6 antibody, transmembrane serine protease 6 antibody, Tmprss6 antibody, TMPRSS6 antibody
- Background
-
TMPRSS6 is a serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. TMPRSS6 can also activate urokinase-type plasminogen activator with low efficiency. TMPRSS6 may play a specialized role in matrix remodeling processes in liver. TMPRSS6 is required to sense iron deficiency. Overexpression of TMPRSS6 suppresses activation of the HAMP promoter.The protein encoded by this gene is a type II transmembrane serine proteinase that is found attached to the cell surface. The encoded protein may be involved in matrix remodeling processes in the liver.
Alias Symbols: IRIDA
Protein Interaction Partner: LAMA1, FN1, COL1A1,
Protein Size: 811 - Molecular Weight
- 90 kDa
- Gene ID
- 164656
- NCBI Accession
- NM_153609, NP_705837
- UniProt
- Q8IU80
- Pathways
- Transition Metal Ion Homeostasis
-