TRAF3IP2 antibody (N-Term)

Catalog No. ABIN2785129

Product Details anti-TRAF3IP2 Antibody

Target: TRAF3IP2 (TRAF3 Interacting Protein 2 (TRAF3IP2))

Binding Specificity: N-Term

Reactivity: Human, Rat, Mouse, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRAF3IP2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: IPVEVDESEP YPSQLLKPIP EYSPEEESEP PAPNIRNMAP NSLSAPTMLH

Predicted Reactivity: Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Rat: 86%

Characteristics: This is a rabbit polyclonal antibody against TRAF3IP2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human TRAF3IP2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 574 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TRAF3IP2

Target: TRAF3IP2 (TRAF3 Interacting Protein 2 (TRAF3IP2))

Alternative Name: TRAF3IP2 (TRAF3IP2 Products)

Background: This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Several alternative transcripts encoding different isoforms have been identified. Another transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene.
Alias Symbols: ACT1, C6orf2, C6orf4, C6orf5, C6orf6, CIKS, DKFZp586G0522, MGC3581, PSORS13
Protein Interaction Partner: RIMBP3, IL17RA, MRPL28, STK16, UBE2V1, TRIP6, TRAF6, SYK, SRSF1, FHL3, ELAVL1, TRAF2, FBXW11, BTRC, UBC, Dlg4, TBK1, IKBKE, TNFRSF13C, TRAF3, CD40, MAP3K7, TRAF3IP2, IKBKG, IKBKB, CHUK, IL17A, MDFI, TRAF5, TRAF1,
Protein Size: 574

Molecular Weight: 65 kDa

Gene ID: 10758

NCBI Accession: NM_147200, NP_671733

UniProt: O43734

Pathways: Production of Molecular Mediator of Immune Response