MTPN antibody (Middle Region)

Catalog No. ABIN2785128

Product Details anti-MTPN Antibody

Target: MTPN (Myotrophin (MTPN))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Dog, Cow, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MTPN antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: GRKPLHYAAD CGQLEILEFL LLKGADINAP DKHHITPLLS AVYEGHVSCV

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%

Characteristics: This is a rabbit polyclonal antibody against MTPN. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human MTPN

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 118 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-MTPN antibody (ABIN2785128)

Nghiem, Hoffman, Mittal, Brown, Schatzberg, Ghimbovschi, Wang, Kornegay: "Sparing of the dystrophin-deficient cranial sartorius muscle is associated with classical and novel hypertrophy pathways in GRMD dogs." in: The American journal of pathology, Vol. 183, Issue 5, pp. 1411-24, (2013) (PubMed).

Target Details for MTPN

Target: MTPN (Myotrophin (MTPN))

Alternative Name: MTPN (MTPN Products)

Background: MTPN has a potential role in cerebellar morphogenesis. MTPN may function in differentiation of cerebellar neurons, particularly of granule cells. MTPN seems to be associated with cardiac hypertrophy.The transcript produced from this gene is bi-cistronic and can encode both myotrophin and leucine zipper protein 6. The myotrophin protein is associated with cardiac hypertrophy, where it is involved in the conversion of NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers. This protein also has a potential function in cerebellar morphogenesis, and it may be involved in the differentiation of cerebellar neurons, particularly of granule cells. A cryptic ORF at the 3' end of this transcript uses a novel internal ribosome entry site and a non-AUG translation initiation codon to produce leucine zipper protein 6, a 6.4 kDa tumor antigen that is associated with myeloproliferative disease.
Alias Symbols: FLJ31098, GCDP, V-1
Protein Interaction Partner: RBBP4, RAB1A, PTPN11, OXCT1, MTAP, PDIA3, ATP6V1A, UBC, NPLOC4, ELAVL1, MAPK1, CAPZB, RELA, NFKB1, REL, DSTYK,
Protein Size: 118

Molecular Weight: 13 kDa

Gene ID: 136319

NCBI Accession: NM_145808, NP_665807

UniProt: P58546