CISH antibody (N-Term)

Catalog No. ABIN2785100

Product Details anti-CISH Antibody

Target: CISH (Cytokine Inducible SH2-Containing Protein (CISH))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Pig, Rabbit, Cow, Horse, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CISH antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: RESGWYWGSI TASEARQHLQ KMPEGTFLVR DSTHPSYLFT LSVKTTRGPT

Predicted Reactivity: Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against Cish. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide corresponding to a region of Mouse

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 257 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CISH

Target: CISH (Cytokine Inducible SH2-Containing Protein (CISH))

Alternative Name: Cish (CISH Products)

Synonyms: CISH antibody, cis antibody, cish.a antibody, ptk9l antibody, twf1l antibody, wu:fk57g04 antibody, zgc:154062 antibody, zgc:91817 antibody, g18 antibody, socs antibody, cis-1 antibody, cish antibody, BACTS2 antibody, CIS antibody, CIS-1 antibody, G18 antibody, SOCS antibody, AI385595 antibody, CIS1 antibody, Cis antibody, F17 antibody, F23 antibody, cytokine inducible SH2 containing protein antibody, cytokine inducible SH2-containing protein antibody, CISH antibody, cish antibody, Cish antibody

Background: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Alias Symbols: AI385595, CIS1, Cis, F17, F23
Protein Interaction Partner: GHR, Socs2, Lepr, Epor, Prkcq, Prkcb, Prkca, Ubc, Abl1, Cul5, TCEB2, TCEB1, Stat5a,
Protein Size: 257

Molecular Weight: 28 kDa

Gene ID: 12700

NCBI Accession: NM_009895, NP_034025

UniProt: Q62225

Pathways: JAK-STAT Signaling, Response to Growth Hormone Stimulus