ASZ1 antibody (Middle Region)
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- Target See all ASZ1 Antibodies
- ASZ1 (Ankyrin Repeat, SAM and Basic Leucine Zipper Domain Containing 1 (ASZ1))
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Binding Specificity
- Middle Region
- Reactivity
- Human, Rat, Mouse, Guinea Pig, Horse, Rabbit, Cow, Dog, Sheep
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This ASZ1 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- GKMPSEIAKR NKHHEIFNLL SFTLNPLEGK LQQLTKEDTI CKILTTDSDR
- Predicted Reactivity
- Cow: 93%, Dog: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 93%
- Characteristics
- This is a rabbit polyclonal antibody against ASZ1. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human ASZ1
- Top Product
- Discover our top product ASZ1 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 475 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- ASZ1 (Ankyrin Repeat, SAM and Basic Leucine Zipper Domain Containing 1 (ASZ1))
- Alternative Name
- ASZ1 (ASZ1 Products)
- Synonyms
- Gasz antibody, GASZ antibody, gasz antibody, MGC56332 antibody, zgc:56332 antibody, ALP1 antibody, ANKL1 antibody, C7orf7 antibody, CT1.19 antibody, Orf3 antibody, 4933400N19Rik antibody, ORF3 antibody, ankyrin repeat, SAM and basic leucine zipper domain containing 1 antibody, Asz1 antibody, ASZ1 antibody, asz1 antibody
- Background
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ASZ1 plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity.ASZ1 acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process.ASZ1 is required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in regulation of retrotransposons.ASZ1 may act by mediating protein-protein interactions during germ cell maturation.
Alias Symbols: ALP1, ANKL1, C7orf7, GASZ, MGC26634, Orf3, CT1.19
Protein Interaction Partner: TSG101,
Protein Size: 475 - Molecular Weight
- 53 kDa
- Gene ID
- 136991
- NCBI Accession
- NM_130768, NP_570124
- UniProt
- Q8WWH4
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