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COPS8 antibody (Middle Region)

COPS8 Reactivity: Human, Rat, Mouse, Horse, Rabbit, Cow, Guinea Pig, Dog WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2784840
  • Target See all COPS8 Antibodies
    COPS8 (COP9 Signalosome Subunit 8 (COPS8))
    Binding Specificity
    • 15
    • 9
    • 5
    • 4
    • 4
    • 2
    • 1
    Middle Region
    Reactivity
    • 54
    • 28
    • 27
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Rat, Mouse, Horse, Rabbit, Cow, Guinea Pig, Dog
    Host
    • 49
    • 5
    Rabbit
    Clonality
    • 52
    • 2
    Polyclonal
    Conjugate
    • 20
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This COPS8 antibody is un-conjugated
    Application
    • 42
    • 20
    • 13
    • 6
    • 5
    • 4
    • 2
    • 2
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequence
    TRMVLPRKPV AGALDVSFNK FIPLSEPAPV PPIPNEQQLA RLTDYVAFLE
    Predicted Reactivity
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%
    Characteristics
    This is a rabbit polyclonal antibody against COPS8. It was validated on Western Blot.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human COPS8
    Top Product
    Discover our top product COPS8 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 209 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Pick, Golan, Zimbler, Guo, Sharaby, Tsuge, Hofmann, Wei: "The minimal deneddylase core of the COP9 signalosome excludes the Csn6 MPN- domain." in: PLoS ONE, Vol. 7, Issue 8, pp. e43980, (2012) (PubMed).

  • Target
    COPS8 (COP9 Signalosome Subunit 8 (COPS8))
    Alternative Name
    COPS8 (COPS8 Products)
    Synonyms
    COP9 antibody, CSN8 antibody, SGN8 antibody, csn8 antibody, cops8 antibody, MGC76051 antibody, MGC80215 antibody, DDBDRAFT_0167123 antibody, DDBDRAFT_0233107 antibody, DDB_0167123 antibody, DDB_0233107 antibody, zgc:56319 antibody, zgc:86840 antibody, MGC86182 antibody, 9430009J09Rik antibody, AA408242 antibody, Csn8 antibody, Sgn8 antibody, CONSTITUTIVE PHOTOMORPHOGENIC 9 antibody, COP9 SIGNALOSOME SUBUNIT 8 antibody, DL3095C antibody, EMB143 antibody, EMBRYO DEFECTIVE 143 antibody, FCAALL.131 antibody, FUS7 antibody, FUSCA 7 antibody, FUSCA PROTEIN FUS7 antibody, CG13383 antibody, CG33297 antibody, CG42522 antibody, CH8 antibody, Dch8 antibody, Dmel\\CG42522 antibody, Dmel_CG13383 antibody, l(2)SH1829 antibody, l(2)SH2 1829 antibody, COP9 signalosome subunit 8 antibody, COP9 signalosome subunit 8 S homeolog antibody, COP9 signalosome complex subunit 8 antibody, COP9 signalosome subunit 8 L homeolog antibody, COP9 signalosome, subunit CSN8 antibody, COPS8 antibody, Cops8 antibody, cops8 antibody, cops8.S antibody, CSN8 antibody, csn8 antibody, cops8.L antibody, COP9 antibody
    Background
    The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
    Alias Symbols: COP9, CSN8, MGC1297, MGC43256, SGN8
    Protein Interaction Partner: USHBP1, GPS1, cul1, WDR77, SRRT, COPS7A, VIM, COPS4, FBXO6, FBXW4, COPS5, vpr, IRF5, DDIT3, COPS2, COPS3, COPS6, PINK1, RFWD2, CUL4A, UBC, LRR1, DDA1, DDB2, DCUN1D1, VPRBP, CUL2, CUL3, CUL4B, CUL5, NEDD8, JUN, GFER, ERCC8, DDB1, CTNNB1, RAE1, COPS8, EIF3E
    Protein Size: 209
    Molecular Weight
    23 kDa
    Gene ID
    10920
    NCBI Accession
    NM_006710, NP_006701
    UniProt
    Q99627
    Pathways
    Cell Division Cycle
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