PACS2 antibody (Middle Region)
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- Target See all PACS2 Antibodies
- PACS2 (phosphofurin Acidic Cluster Sorting Protein 2 (PACS2))
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Binding Specificity
- Middle Region
- Reactivity
- Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Zebrafish (Danio rerio)
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This PACS2 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- AHQLPIAEAM LTYKQKSPDE ESSQKFIPFV GVVKVGIVEP SSATSGDSDD
- Predicted Reactivity
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%, Zebrafish: 86%
- Characteristics
- This is a rabbit polyclonal antibody against PACS2. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human PACS2
- Top Product
- Discover our top product PACS2 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 889 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- PACS2 (phosphofurin Acidic Cluster Sorting Protein 2 (PACS2))
- Alternative Name
- PACS2 (PACS2 Products)
- Synonyms
- PACS-2 antibody, PACS1L antibody, 6720425G15Rik antibody, AW208651 antibody, AW489976 antibody, E230011J22 antibody, Pacs1l antibody, mKIAA0602 antibody, phosphofurin acidic cluster sorting protein 2 antibody, PACS2 antibody, Pacs2 antibody
- Background
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PACS2 is the multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptic inducer,PACS2 translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death.PACS2 may also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments.
Alias Symbols: FLJ25488, KIAA0602, PACS1L, PACS-2
Protein Interaction Partner: UBC, TRAF2, BIRC3, BIRC2, PKD2, BID,
Protein Size: 889 - Molecular Weight
- 98 kDa
- Gene ID
- 23241
- NCBI Accession
- NM_015197, NP_056012
- UniProt
- Q86VP3
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