PYHIN1 antibody (N-Term)

Catalog No. ABIN2784367

Product Details anti-PYHIN1 Antibody

Target: PYHIN1 (Pyrin and HIN Domain Family, Member 1 (PYHIN1))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Cow, Dog, Pig, Rabbit, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PYHIN1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: ANNYKKIVLL KGLEVINDYH FRIVKSLLSN DLKLNPKMKE EYDKIQIADL

Predicted Reactivity: Cow: 91%, Dog: 91%, Horse: 91%, Human: 100%, Mouse: 100%, Pig: 85%, Rabbit: 93%, Rat: 85%

Characteristics: This is a rabbit polyclonal antibody against PYHIN1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PYHIN1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 492 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PYHIN1

Target: PYHIN1 (Pyrin and HIN Domain Family, Member 1 (PYHIN1))

Alternative Name: PYHIN1 (PYHIN1 Products)

Synonyms: IFIX antibody, RP11-520H16.1 antibody, 4930422C14 antibody, AI447904 antibody, Ifi209 antibody, Ifix antibody, pyrin and HIN domain family member 1 antibody, interferon activated gene 209 antibody, PYHIN1 antibody, Ifi209 antibody

Background: PYHIN1 belongs to the HIN-200 family. This protein is major mediator of the tumor suppressor activity of IFN in breast cancer cells. It promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization, and HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells.
Alias Symbols: IFIX, MGC23885, RP11-520H16.1
Protein Interaction Partner: MDM2,
Protein Size: 492

Molecular Weight: 55 kDa

Gene ID: 149628

NCBI Accession: NM_152501, NP_689714

UniProt: Q6K0P9