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SPRY2 antibody (N-Term)

SPRY2 Reactivity: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Pig, Guinea Pig WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2784217
  • Target See all SPRY2 Antibodies
    SPRY2 (Sprouty Homolog 2 (SPRY2))
    Binding Specificity
    • 9
    • 7
    • 6
    • 6
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 40
    • 20
    • 10
    • 7
    • 4
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Pig, Guinea Pig
    Host
    • 40
    • 3
    • 1
    • 1
    Rabbit
    Clonality
    • 42
    • 3
    Polyclonal
    Conjugate
    • 31
    • 4
    • 3
    • 3
    • 2
    • 2
    This SPRY2 antibody is un-conjugated
    Application
    • 37
    • 25
    • 12
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequence
    MEARAQSGNG SQPLLQTPRD GGRQRGEPDP RDALTQQVHV LSLDQIRAIR
    Predicted Reactivity
    Cow: 93%, Dog: 100%, Guinea Pig: 92%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 86%, Rat: 100%
    Characteristics
    This is a rabbit polyclonal antibody against SPRY2. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human SPRY2
    Top Product
    Discover our top product SPRY2 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 315 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Hsu, Lee, Hartstein, Harocopos: "Clostridium perfringens Keratitis Leading to Blinding Panophthalmitis." in: Cornea, Vol. 27, Issue 10, pp. 1200-3, (2008) (PubMed).

  • Target
    SPRY2 (Sprouty Homolog 2 (SPRY2))
    Alternative Name
    SPRY2 (SPRY2 Products)
    Synonyms
    wu:fk66h11 antibody, wu:fk93e11 antibody, zgc:110440 antibody, hspry2 antibody, xspry2 antibody, sprouty2 antibody, Xsprouty2 antibody, sprouty-2 antibody, Xtsprouty2 antibody, hSPRY2 antibody, sprouty RTK signaling antagonist 2 antibody, sprouty RTK signaling antagonist 2 S homeolog antibody, sprouty homolog 2 (Drosophila) antibody, spry2 antibody, SPRY2 antibody, spry2.S antibody, Spry2 antibody
    Background
    SPRY2 is a protein belonging to the sprouty family. It contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. SPRY2 is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. SPRY2 may play a role in alveoli branching during lung development as shown by a similar mouse protein.This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
    Alias Symbols: MGC23039, hSPRY2
    Protein Interaction Partner: PTGER3, PRKAB2, KRTAP4-11, ATRIP, KRTAP5-6, KRTAP10-3, KRTAP10-8, KRTAP10-5, KRTAP10-11, KRTAP10-1, KRTAP10-9, LCE3E, KRTAP5-9, GP9, OTX1, MLLT6, MEOX2, MDFI, LASP1, LCE2D, LCE1B, RUNX1T1, AQP1, LCE3C, LCE4A, ZNF417, HEXIM2, CATSPER1, LONRF1, KRTAP4-7, KR
    Protein Size: 315
    Molecular Weight
    35 kDa
    Gene ID
    10253
    NCBI Accession
    NM_005842, NP_005833
    UniProt
    O43597
    Pathways
    EGFR Signaling Pathway, Sensory Perception of Sound, EGFR Downregulation
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