ADAM19 antibody (N-Term)

Catalog No. ABIN2783899

Product Details anti-ADAM19 Antibody

Target: ADAM19 (Adam19) (ADAM Metallopeptidase Domain 19 (Adam19))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Rabbit, Dog, Cow, Guinea Pig, Horse, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ADAM19 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: VADYLEFQKN RRDQDATKHK LIEIANYVDK FYRSLNIRIA LVGLEVWTHG

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 93%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against ADAM19. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ADAM19

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 956 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-ADAM19 antibody (ABIN2783899)

Marballi, Cruz, Thompson, Walss-Bass: "Differential neuregulin 1 cleavage in the prefrontal cortex and hippocampus in schizophrenia and bipolar disorder: preliminary findings." in: PLoS ONE, Vol. 7, Issue 5, pp. e36431, (2012) (PubMed).

Target Details for ADAM19

Target: ADAM19 (Adam19) (ADAM Metallopeptidase Domain 19 (Adam19))

Alternative Name: ADAM19 (Adam19 Products)

Synonyms: AL024287 antibody, M[b] antibody, Mltnb antibody, MADDAM antibody, MLTNB antibody, Sox30 antibody, fksg34 antibody, maddam antibody, mltnb antibody, a disintegrin and metallopeptidase domain 19 (meltrin beta) antibody, ADAM metallopeptidase domain 19 antibody, ADAM metallopeptidase domain 19 S homeolog antibody, Adam19 antibody, ADAM19 antibody, adam19.S antibody

Background: ADAM19 is a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has also been demonstrated to be an active metalloproteinase, which may be involved in normal physiological and pathological processes such as cells migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction. Alternative splicing results in two transcript variants.This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has also been demonstrated to be an active metalloproteinase, which may be involved in normal physiological and pathological processes such as cells migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction. Alternative splicing results in two transcript variants.
Alias Symbols: FKSG34, MADDAM, MLTNB
Protein Interaction Partner: UBC, TNFSF11, COPB1, NRG1, FURIN, A2M, ABI2, SH3GL2, ESF1,
Protein Size: 956

Molecular Weight: 82 kDa

Gene ID: 8728

NCBI Accession: NM_023038, NP_075525

UniProt: Q9H013