SRPRB antibody (Middle Region)

Catalog No. ABIN2783830

Product Details anti-SRPRB Antibody

Target: SRPRB (Signal Recognition Particle Receptor, B Subunit (SRPRB))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Dog, Horse, Rabbit, Cow, Saccharomyces cerevisiae, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SRPRB antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: QDIAMAKSAK LIQQQLEKEL NTLRVTRSAA PSTLYSSSTA PAQLGKKGKE

Predicted Reactivity: Cow: 93%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against SRPRB. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human SRPRB

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 271 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-SRPRB antibody (ABIN2783830)

Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: "Large-scale mapping of human protein-protein interactions by mass spectrometry. ..." in: Molecular systems biology, Vol. 3, pp. 89, (2007) (PubMed).

Target Details for SRPRB

Target: SRPRB (Signal Recognition Particle Receptor, B Subunit (SRPRB))

Alternative Name: SRPRB (SRPRB Products)

Synonyms: wu:fk57h10 antibody, zgc:111820 antibody, zgc:92746 antibody, apmcf1 antibody, APMCF1 antibody, AA409543 antibody, Ab2-417 antibody, Ba1-667 antibody, Cc1-8 antibody, signal recognition particle receptor, B subunit antibody, SRP receptor beta subunit S homeolog antibody, SRP receptor beta subunit antibody, SRPRB antibody, srprb antibody, srprb.S antibody, Srprb antibody

Background: SRPRB has similarity to mouse protein which is a subunit of the signal recognition particle receptor (SR). This subunit is a transmembrane GTPase belonging to the GTPase superfamily. It anchors alpha subunit, a peripheral membrane GTPase, to the ER membrane. SR is required for the cotranslational targeting of both secretory and membrane proteins to the ER membrane.The protein encoded by this gene has similarity to mouse protein which is a subunit of the signal recognition particle receptor (SR). This subunit is a transmembrane GTPase belonging to the GTPase superfamily. It anchors alpha subunit, a peripheral membrane GTPase, to the ER membrane. SR is required for the cotranslational targeting of both secretory and membrane proteins to the ER membrane.The protein encoded by this gene has similarity to mouse protein which is a subunit of the signal recognition particle receptor (SR). This subunit is a transmembrane GTPase belonging to the GTPase superfamily. It anchors alpha subunit, a peripheral membrane GTPase, to the ER membrane. SR is required for the cotranslational targeting of both secretory and membrane proteins to the ER membrane.
Alias Symbols: APMCF1
Protein Interaction Partner: ERLIN2, UBC, STAU1, MDM2, FBXO6, PPP6R1, ADRB2, LMNA, UBL4A, CA9, UBE2L3, TAGLN, SPR, SNRPC, S100A10, RRBP1, RPL38, RFX5, RBMS1, PIN4, PFN1, ACAA1, TMED4, TMEM65, RPS10P5, MRRF, SARNP, NABP2, MRPL14, TMBIM1, SUGP1, SBDS, MRPS28, TARDBP, TOMM40, UBE4B, SF3
Protein Size: 271

Molecular Weight: 30 kDa

Gene ID: 58477

NCBI Accession: NM_021203, NP_067026

UniProt: Q9Y5M8

Pathways: ER-Nucleus Signaling