Junctophilin 3 antibody (N-Term)

Catalog No. ABIN2783795

Product Details anti-Junctophilin 3 Antibody

Target: Junctophilin 3 (JPH3)

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Pig, Rabbit, Zebrafish (Danio rerio), Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Junctophilin 3 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: SSGGRFNFDD GGSYCGGWED GKAHGHGVCT GPKGQGEYTG SWSHGFEVLG

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 85%, Rat: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against JPH3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human JPH3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 748 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Junctophilin 3

Target: Junctophilin 3 (JPH3)

Alternative Name: JPH3 (JPH3 Products)

Synonyms: CAGL237 antibody, HDL2 antibody, JP-3 antibody, JP3 antibody, TNRC22 antibody, Jp3 antibody, fc26e06 antibody, si:ch211-255l14.9 antibody, wu:fc26e06 antibody, junctophilin 3 antibody, JPH3 antibody, Jph3 antibody, jph3 antibody

Background: Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. JPH3 is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic domain that shows specific affinity for the plasma membrane. CAG/CTG repeat expansions at the Huntington's disease (HD)-like 2 locus have been identified in the gene that encodes JPH3 protein. Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. The protein encoded by this gene is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic domain that shows specific affinity for the plasma membrane. CAG/CTG repeat expansions at the Huntington's disease (HD)-like 2 locus have been identified in this gene, which is a member of the junctophilin gene family. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: CAGL237, FLJ44707, HDL2, JP-3, JP3, TNRC22
Protein Interaction Partner: PPP1CA, SMAD3, BGN, STK24,
Protein Size: 748

Molecular Weight: 81 kDa

Gene ID: 57338

NCBI Accession: NM_020655, NP_065706

UniProt: Q8WXH2