TMCO1 antibody (C-Term)

Catalog No. ABIN2783742

Product Details anti-TMCO1 Antibody

Target: TMCO1 (Transmembrane and Coiled-Coil Domains 1 (TMCO1))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TMCO1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: CSFIFLYILC TMSIRQNIQK ILGLAPSRAA TKQAGGFLGP PPPSGKFS

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against TMCO1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human TMCO1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 188 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-TMCO1 antibody (ABIN2783742)

Sharma, Burdon, Chidlow, Klebe, Crawford, Dimasi, Dave, Martin, Javadiyan, Wood, Casson, Danoy, Griggs, Hewitt, Landers, Mitchell, Mackey, Craig: "Association of genetic variants in the TMCO1 gene with clinical parameters related to glaucoma and characterization of the protein in the eye." in: Investigative ophthalmology & visual science, Vol. 53, Issue 8, pp. 4917-25, (2012) (PubMed).

Burdon, Macgregor, Hewitt, Sharma, Chidlow, Mills, Danoy, Casson, Viswanathan, Liu, Landers, Henders, Wood, Souzeau, Crawford, Leo, Wang, Rochtchina, Nyholt, Martin, Montgomery, Mitchell, Brown et al.: "Genome-wide association study identifies susceptibility loci for open angle glaucoma at TMCO1 and CDKN2B-AS1. ..." in: Nature genetics, Vol. 43, Issue 6, pp. 574-8, (2011) (PubMed).

Target Details for TMCO1

Target: TMCO1 (Transmembrane and Coiled-Coil Domains 1 (TMCO1))

Alternative Name: TMCO1 (TMCO1 Products)

Synonyms: DKFZp459A2226 antibody, sb:cb729 antibody, zgc:110322 antibody, zgc:92740 antibody, HP10122 antibody, PCIA3 antibody, PNAS-136 antibody, RP11-466F5.7 antibody, TMCC4 antibody, 1190006A08Rik antibody, 4930403O06Rik antibody, AA109065 antibody, AU022572 antibody, ESTM39 antibody, transmembrane and coiled-coil domains 1 antibody, transmembrane and coiled-coil domains 1 S homeolog antibody, TMCO1 antibody, tmco1 antibody, tmco1.S antibody, Tmco1 antibody

Background: TMCO1 belongs to the TMCO1 family. The exact function of TMCO1 remains unknown.
Alias Symbols: HP10122, PCIA3, PNAS-136, RP11-466F5.7, TMCC4
Protein Interaction Partner: UBC, FBXO6, SERINC1, LAMTOR3, SRSF5, RPS10, ABCC1, ELAVL1, UNC93B1,
Protein Size: 188

Molecular Weight: 21 kDa

Gene ID: 54499

NCBI Accession: NM_019026, NP_061899

UniProt: Q9UM00