PCDHGC4 antibody (N-Term)

Catalog No. ABIN2783728

Product Details anti-PCDHGC4 Antibody

Target: PCDHGC4 (Protocadherin gamma Subfamily C, 4 (PCDHGC4))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Horse, Zebrafish (Danio rerio), Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PCDHGC4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: VKKRSDGSLV PELLLEKPLD REKQSDYRLV LTAVDGGNPP RSGTAELRVS

Predicted Reactivity: Horse: 100%, Human: 100%, Mouse: 100%, Pig: 91%, Rabbit: 79%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against PCDHGC4. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PCDHGC4

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 938 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PCDHGC4

Target: PCDHGC4 (Protocadherin gamma Subfamily C, 4 (PCDHGC4))

Alternative Name: PCDHGC4 (PCDHGC4 Products)

Synonyms: PCDH-GAMMA-C4 antibody, protocadherin gamma c4 antibody, protocadherin gamma subfamily C, 4 antibody, Pcdhgc4 antibody, PCDHGC4 antibody

Background: PCDHGC4 is a single-pass type I membrane protein. It contains 6 cadherin domains.PCDHGC4 is a potential calcium-dependent cell-adhesion protein. It may be involved in the establishment and maintenance of specific neuronal connections in the brain.This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.
Alias Symbols: MGC119489, PCDH-GAMMA-C4
Protein Size: 938

Molecular Weight: 98 kDa

Gene ID: 56098

NCBI Accession: NM_018928, NP_061751

UniProt: Q9Y5F7