PCDHA5 antibody (N-Term)

Catalog No. ABIN2783723

Product Details anti-PCDHA5 Antibody

Target: PCDHA5 (Protocadherin alpha 5 (PCDHA5))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PCDHA5 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: VYSRRGSLGS RLLLLWLLLA YWKAGSGQLH YSIPEEAKHG TFVGRIAQDL

Predicted Reactivity: Cow: 86%, Dog: 79%, Guinea Pig: 93%, Horse: 86%, Human: 100%, Mouse: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against PCDHA5. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PCDHA5

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 936 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PCDHA5

Target: PCDHA5 (Protocadherin alpha 5 (PCDHA5))

Alternative Name: PCDHA5 (PCDHA5 Products)

Synonyms: CNR6 antibody, CNRN6 antibody, CNRS6 antibody, CRNR6 antibody, PCDH-ALPHA5 antibody, Cnr6 antibody, Crnr6 antibody, rCNRv05 antibody, PCDHA5 antibody, Pcdha5 antibody, protocadherin alpha 5 antibody, protocadherin alpha-5 antibody, PCDHA5 antibody, Pcdha5 antibody, LOC100738784 antibody, LOC100847156 antibody, LOC100713870 antibody, LOC100629824 antibody

Background: The gene encoding PCDHA5 is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. PCDHA5 is a single-pass type I membrane protein. It contains 6 cadherin domains. PCDHA5 is a potential calcium-dependent cell-adhesion protein. It may be involved in the establishment and maintenance of specific neuronal connections in the brain.This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.
Alias Symbols: CNR6, CNRN6, CNRS6, CRNR6, PCDH-ALPHA5
Protein Size: 936

Molecular Weight: 99 kDa

Gene ID: 56143

NCBI Accession: NM_018908, NP_061731

UniProt: Q9Y5H7