NEK11 antibody (Middle Region)

Catalog No. ABIN2783561

Product Details anti-NEK11 Antibody

Target: NEK11 (NIMA (Never In Mitosis Gene A)-Related Kinase 11 (NEK11))

Binding Specificity: Middle Region

Reactivity: Human, Rat, Cow, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NEK11 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: KEIRNEGSQP AYRTNQQDSD IEALARCLEN VLGCTSLDTK TITTMAEDMS

Predicted Reactivity: Cow: 77%, Horse: 100%, Human: 100%, Rat: 79%

Characteristics: This is a rabbit polyclonal antibody against NEK11. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human NEK11

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 645 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for NEK11

Target: NEK11 (NIMA (Never In Mitosis Gene A)-Related Kinase 11 (NEK11))

Alternative Name: NEK11 (NEK11 Products)

Synonyms: nek11 antibody, MGC147549 antibody, 4932416N14Rik antibody, NIMA-related kinase 11 antibody, NIMA (never in mitosis gene a)-related expressed kinase 11 antibody, NIMA related kinase 11 antibody, nek11 antibody, Nek11 antibody, NEK11 antibody

Background: NEK11 is a member of the never in mitosis gene A family of kinases. NEK11 localizes to the nucleoli, and may function with NEK2A in the S-phase checkpoint. It appears to play roles in DNA replication and response to genotoxic stress. NEK11 belongs to the NIMA family of kinases, which are involved in DNA replication and genotoxic stress responses (Noguchi et al., 2002 [PubMed 12154088]).[supplied by OMIM]. Sequence Note: removed 2 bases from the 3' end that did not align to the reference genome assembly. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-2937 AB071996.1 1-2937
Alias Symbols: FLJ23495
Protein Interaction Partner: MYC, HSP90AA1, APP, NEK11, NEK2,
Protein Size: 645

Molecular Weight: 74 kDa

Gene ID: 79858

NCBI Accession: NM_024800, NP_079076

UniProt: Q8NG66