TPI1 antibody (N-Term)

Catalog No. ABIN310985

Product Details anti-TPI1 Antibody

Target: TPI1 (Triosephosphate Isomerase 1 (TPI1))

Binding Specificity: N-Term

Reactivity: Human, Rabbit, Dog, Cow, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TPI1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: MAPSRKFFVG GNWKMNGRKQ SLGELIGTLN AAKVPADTEV VCAPPTAYID

Predicted Reactivity: Cow: 79%, Dog: 79%, Guinea Pig: 79%, Horse: 86%, Human: 100%, Rabbit: 79%

Characteristics: This is a rabbit polyclonal antibody against TPI1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human TPI1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 249 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-TPI1 antibody (ABIN310985)

Ralser, Nebel, Kleindorp, Krobitsch, Lehrach, Schreiber, Reinhardt, Timmermann: "Sequencing and genotypic analysis of the triosephosphate isomerase (TPI1) locus in a large sample of long-lived Germans." in: BMC genetics, Vol. 9, pp. 38, (2008) (PubMed).

Target Details for TPI1

Target: TPI1 (Triosephosphate Isomerase 1 (TPI1))

Alternative Name: TPI1 (TPI1 Products)

Background: TPI1 belongs to the triosephosphate isomerase family. Defects in TPI1 are the cause of triosephosphate isomerase deficiency (TPI deficiency) . TPI deficiency is an autosomal recessive disorder. It is the most severe clinical disorder of glycolysis. It is associated with neonatal jaundice, chronic hemolytic anemia, progressive neuromuscular dysfunction, cardiomyopathy and increased susceptibility to infection.
Alias Symbols: MGC88108, TPI, TIM
Protein Interaction Partner: MDM2, UBC, RNF2, EZH2, SUZ12, TARDBP, YWHAQ, SP1, UBD, HCVgp1, IQCB1, ATF2, LIG4, SSU72, SEC23IP, PDIA6, PRDX6, VCL, UBA52, TKT, PGK1, MPST, GPI, GAPDH, ENO1, APP, CUL1, CDK2, TERF1, POT1, PSMA3, MAPK6, PCNA, HDAC5, UCHL5, EGFR, LIPT1, SETDB1, DDX24, CFL1
Protein Size: 249

Molecular Weight: 27 kDa

Gene ID: 7167

NCBI Accession: NM_000365, NP_000356

UniProt: P60174

Pathways: Cell RedoxHomeostasis