OAT antibody (Middle Region)

Catalog No. ABIN2783233

Product Details anti-OAT Antibody

Target: OAT (Ornithine Aminotransferase (OAT))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Cow, Horse, Rabbit, Dog, Guinea Pig, Zebrafish (Danio rerio), Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OAT antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: RTLSAISSST DPTSYDGFGP FMPGFDIIPY NDLPALERAL QDPNVAAFMV

Predicted Reactivity: Cow: 100%, Dog: 93%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against OAT. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human OAT

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 439 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-OAT antibody (ABIN2783233)

Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: "Large-scale mapping of human protein-protein interactions by mass spectrometry. ..." in: Molecular systems biology, Vol. 3, pp. 89, (2007) (PubMed).

Target Details for OAT

Target: OAT (Ornithine Aminotransferase (OAT))

Abstract: OAT Products

Synonyms: 151832_at antibody, CG8782 antibody, Dmel\\CG8782 antibody, hoga antibody, AI194874 antibody, rOAT antibody, GACR antibody, HOGA antibody, OATASE antibody, OKT antibody, Ornithine aminotransferase precursor antibody, ornithine aminotransferase, gene 1 antibody, ornithine aminotransferase antibody, Oat antibody, oat.1 antibody, OAT antibody, Lbys_2951 antibody, Riean_0998 antibody, Ftrac_2019 antibody, Celal_2605 antibody, Deipr_1149 antibody, Celly_0230 antibody, Weevi_2065 antibody, Fluta_4071 antibody, Halhy_2848 antibody, Theth_0565 antibody, oat antibody

Background: OAT is a key enzyme in the pathway that converts arginine and ornithine into the major excitatory and inhibitory neurotransmitters glutamate and GABA. Mutations of this enzyme cause the autosomal recessive eye disease Gyrate Atrophy. This gene encodes the mitochondrial enzyme ornithine aminotransferase, which is a key enzyme is the pathway that converts arginine and ornithine into the major excitatory and inhibitory neurotransmitters glutamate and GABA. Mutations that result in a deficiency of this enzyme cause the autosomal recessive eye disease Gyrate Atrophy. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-42 DB459793.1 27-68 43-2062 BC016928.1 1-2020 2063-2066 M12267.1 2010-2013
Alias Symbols: DKFZp781A11155, HOGA, OKT, GACR, OATASE
Protein Interaction Partner: FUS, HUWE1, SUMO2, STAU1, UBC, ADRB2, ATF2, CTSA, FBXO6, UBQLN4, CDK2, SIRT7, NUDT3, HDAC5, MYC, ICT1, OTUD4, DMWD, SLC35F6, OAT, EIF6,
Protein Size: 439

Molecular Weight: 45 kDa

Gene ID: 4942

NCBI Accession: NM_000274, NP_000265

UniProt: P04181