STING/TMEM173 antibody (Middle Region)

Catalog No. ABIN2783202

Product Details anti-STING/TMEM173 Antibody

Target: STING/TMEM173 (TMEM173) (Transmembrane Protein 173 (TMEM173))

Binding Specificity: Middle Region

Reactivity: Human, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STING/TMEM173 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: DPNIRFLDKL PQQTGDHAGI KDRVYSNSIY ELLENGQRAG TCVLEYATPL

Predicted Reactivity: Human: 100%, Pig: 83%

Characteristics: This is a rabbit polyclonal antibody against TMEM173. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TMEM173

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 379 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-STING/TMEM173 antibody (ABIN2783202)

Panchanathan, Liu, Xin, Choubey: "Identification of a negative feedback loop between cyclic di-GMP-induced levels of IFI16 and p202 cytosolic DNA sensors and STING." in: Innate immunity, Vol. 20, Issue 7, pp. 751-9, (2014) (PubMed).

Duan, Ponomareva, Veeranki, Panchanathan, Dickerson, Choubey: "Differential roles for the interferon-inducible IFI16 and AIM2 innate immune sensors for cytosolic DNA in cellular senescence of human fibroblasts." in: Molecular cancer research : MCR, Vol. 9, Issue 5, pp. 589-602, (2011) (PubMed).

Gerhard, Wagner, Feingold, Shenmen, Grouse, Schuler, Klein, Old, Rasooly, Good, Guyer, Peck, Derge, Lipman, Collins, Jang, Sherry, Feolo, Misquitta, Lee, Rotmistrovsky, Greenhut, Schaefer, Buetow et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ..." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, (2004) (PubMed).

Target Details for STING/TMEM173

Target: STING/TMEM173 (TMEM173) (Transmembrane Protein 173 (TMEM173))

Alternative Name: TMEM173 (TMEM173 Products)

Background: TMEM173 acts as a facilitator of innate immune signaling. It is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon (IFN-alpha and IFN-beta) and exert a potent anti-viral state following expression. TMEM173 may be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons.It also may be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). TMEM173 mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.
Alias Symbols: FLJ38577, ERIS, MITA, MPYS, NET23, STING
Protein Interaction Partner: MAVS, TBK1, UBC, TRAF3, IRF3, TOMM70A, TSPAN6, TRIM32, STT3B, TMEM259, YIPF5, HM13, CLPTM1L, MBOAT7, CCDC47, SEC61A1, CNNM3, LTN1, SLC39A14, GLMN, SGPL1, SURF4, RNF5, ABCC1, STT3A, IRAK1, ACSL3, DDOST, NPC1, TMEM173, TRIM56,
Protein Size: 379

Molecular Weight: 42 kDa

Gene ID: 340061

NCBI Accession: NM_198282, NP_938023

UniProt: Q86WV6

Pathways: Activation of Innate immune Response