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NDE1 antibody (Middle Region)

NDE1 Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio) WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2783161
  • Target See all NDE1 Antibodies
    NDE1
    Binding Specificity
    • 7
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio)
    Host
    • 16
    • 3
    Rabbit
    Clonality
    • 16
    • 3
    Polyclonal
    Conjugate
    • 14
    • 1
    • 1
    • 1
    • 1
    • 1
    This NDE1 antibody is un-conjugated
    Application
    • 17
    • 13
    • 5
    • 5
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    AHRGPSSSLN TPGSFRRGLD DSTGGTPLTP AARISALNIV GDLLRKVGAL
    Predicted Reactivity
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 92%
    Characteristics
    This is a rabbit polyclonal antibody against NDE1. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human NDE1
    Top Product
    Discover our top product NDE1 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 335 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Burdick, Kamiya, Hodgkinson, Lencz, DeRosse, Ishizuka, Elashvili, Arai, Goldman, Sawa, Malhotra: "Elucidating the relationship between DISC1, NDEL1 and NDE1 and the risk for schizophrenia: evidence of epistasis and competitive binding." in: Human molecular genetics, Vol. 17, Issue 16, pp. 2462-73, (2008) (PubMed).

  • Target
    NDE1
    Alternative Name
    NDE1 (NDE1 Products)
    Synonyms
    2810027M15Rik antibody, AU042936 antibody, AW822251 antibody, Nude antibody, mNudE antibody, HOM-TES-87 antibody, LIS4 antibody, NDE antibody, NUDE antibody, NUDE1 antibody, fb82g01 antibody, im:7141877 antibody, wu:fb82g01 antibody, zgc:114109 antibody, nudE neurodevelopment protein 1 antibody, Nde1 antibody, NDE1 antibody, nde1 antibody
    Background
    NDE1 is required for centrosome duplication and formation and function of the mitotic spindle. It is essential for the development of the cerebral cortex. NDE1 may regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a post-mitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex
    Alias Symbols: FLJ20101, HOM-TES-87, NUDE, NUDE1, LIS4
    Protein Interaction Partner: FAM9B, LZTS2, USHBP1, NDEL1, ZNF398, NDE1, WAC, UBQLN1, MED4, DISC1, TFIP11, CEP250, NDC80, ARNT2, BZRAP1, MKRN3, TTC1, TRIM27, REL, HOXA2, GOLGA2, AR, YWHAQ, PAFAH1B1, ZNF365, YWHAG, TUBG1, MAPK1, CDK1,
    Protein Size: 335
    Molecular Weight
    38 kDa
    Gene ID
    54820
    NCBI Accession
    NM_017668, NP_060138
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