SMC3 antibody (C-Term)

Catalog No. ABIN2783035

Product Details anti-SMC3 Antibody

Target: SMC3 (Structural Maintenance of Chromosomes 3 (SMC3))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Rabbit, Zebrafish (Danio rerio), Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMC3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: GKATLVMKKG DVEGSQSQDE GEGSGESERG SGSQSSVPSV DQFTGVGIRV

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%

Characteristics: This is a rabbit polyclonal antibody against SMC3. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human SMC3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 681 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SMC3

Target: SMC3 (Structural Maintenance of Chromosomes 3 (SMC3))

Alternative Name: SMC3 (SMC3 Products)

Background: SMC3 belongs to the SMC3 subfamily of SMC proteins. SMC3 occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation.
Alias Symbols: BAM, BMH, CDLS3, CSPG6, HCAP, SMC3L1
Protein Interaction Partner: SUMO2, UBC, RPA3, RPA2, RPA1, SUZ12, EED, RNF2, FBXO6, ANKRD28, HDAC11, HDAC8, HDAC9, SOX2, RAD21, CDCA5, PDS5A, WAPAL, MMS19, METTL21B, NOTCH1, SMC1A, SFPQ, HNRNPM, NSMCE2, UBD, COPS5, COPS6, CUL2, CUL3, NEDD8, CDK2, FBXO25, MECP2, NIPBL, CDK8, SUPT5H, P
Protein Size: 681

Molecular Weight: 74 kDa

Gene ID: 9126

NCBI Accession: NM_005445

UniProt: Q9UQE7

Pathways: Stem Cell Maintenance