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ADCY10 antibody (N-Term)

ADCY10 Reactivity: Human, Rat, Mouse, Rabbit, Cow, Dog, Guinea Pig, Horse WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2782970
  • Target See all ADCY10 Antibodies
    ADCY10 (Adenylate Cyclase 10 (Soluble) (ADCY10))
    Binding Specificity
    • 15
    • 7
    • 6
    • 6
    • 6
    • 2
    • 2
    • 1
    N-Term
    Reactivity
    Human, Rat, Mouse, Rabbit, Cow, Dog, Guinea Pig, Horse
    Host
    • 35
    Rabbit
    Clonality
    • 35
    Polyclonal
    Conjugate
    • 9
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ADCY10 antibody is un-conjugated
    Application
    • 20
    • 19
    • 13
    • 13
    • 12
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    VGHTVRHEYT VIGQKVNLAA RMMMYYPGIV TCDSVTYNGS NLPAYFFKEL
    Predicted Reactivity
    Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%
    Characteristics
    This is a rabbit polyclonal antibody against SAC. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human SAC
    Top Product
    Discover our top product ADCY10 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 1610 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Corredor, Trakhtenberg, Pita-Thomas, Jin, Hu, Goldberg: "Soluble adenylyl cyclase activity is necessary for retinal ganglion cell survival and axon growth." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 32, Issue 22, pp. 7734-44, (2012) (PubMed).

  • Target
    ADCY10 (Adenylate Cyclase 10 (Soluble) (ADCY10))
    Alternative Name
    SAC (ADCY10 Products)
    Synonyms
    HCA2 antibody, RP1-313L4.2 antibody, SAC antibody, SACI antibody, Sacy antibody, Sac antibody, 4930431D04Rik antibody, 4931412F17 antibody, sAC antibody, ADCY10 antibody, SACY antibody, adenylate cyclase 10 antibody, adenylate cyclase 10 (soluble) antibody, ADCY10 antibody, Adcy10 antibody
    Background
    SAC belongs to a distinct class of mammalian adenylyl cyclase that is soluble and insensitive to G protein or forskolin regulation. It is localized in the cytoplasm and is thought to function as a general bicarbonate sensor throughout the body. It may also play an important role in the generation of cAMP in spermatozoa, implying possible roles in sperm maturation through the epididymis, capacitation, hypermotility, and/or the acrosome reaction.The protein encoded by this gene belongs to a distinct class of mammalian adenylyl cyclase that is soluble and insensitive to G protein or forskolin regulation. It is localized in the cytoplasm and is thought to function as a general bicarbonate sensor throughout the body. It may also play an important role in the generation of cAMP in spermatozoa, implying possible roles in sperm maturation through the epididymis, capacitation, hypermotility, and/or the acrosome reaction. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
    Alias Symbols: HCA2, RP1-313L4.2, SACI, SAC, Sacy
    Protein Interaction Partner: PTGIR, SSTR5,
    Protein Size: 1610
    Molecular Weight
    187 kDa
    Gene ID
    55811
    NCBI Accession
    NM_018417, NP_060887
    UniProt
    Q96PN6
    Pathways
    cAMP Metabolic Process
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