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NAGPA antibody (N-Term)
NAGPA
Reactivity: Human, Cow, Dog, Guinea Pig, Horse, Mouse, Rat, Zebrafish (Danio rerio)
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-NAGPA Antibody
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Target
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NAGPA
(N-Acetylglucosamine-1-phosphodiester alpha-N-Acetylglucosaminidase (NAGPA))
Binding Specificity
All epitopes for NAGPA antibodies
N-Term
Reactivity
All reactivities for NAGPA antibodies
Human, Cow, Dog, Guinea Pig, Horse, Mouse, Rat, Zebrafish (Danio rerio)
Host
All hosts for NAGPA antibodies
Rabbit
Clonality
All clonalities for NAGPA antibodies
Polyclonal
Conjugate
All conjugates for NAGPA antibodies
This NAGPA antibody is un-conjugated
Application
All applications for NAGPA antibodies
Western Blotting (WB)
Sequence
GECLGNVVSD ERRVSSSGGL QNAQFGIRRD GTLVTGYLSE EEVLDTENPF
Predicted Reactivity
Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%, Zebrafish: 86%
Characteristics
This is a rabbit polyclonal antibody against NAGPA. It was validated on Western Blot.
Purification
Affinity Purified
Immunogen
The immunogen is a synthetic peptide directed towards the N-terminal region of Human NAGPA
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Discover our top product NAGPA Primary Antibody
Alternatives
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anti-N-Acetylglucosamine-1-phosphodiester alpha-N-Acetylglucosaminidase (NAGPA) (AA 146-195) antibody
NAGPA
Reactivity: Human, Cow, Dog, Guinea Pig, Horse, Mouse, Rat, Zebrafish (Danio rerio), Bat, Chicken, Hamster, Monkey, Pig
WB
Host: Rabbit
Polyclonal
unconjugated
Application Details
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Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1 mg/mL
Buffer
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeat freeze-thaw cycles.
Storage
-20 °C
Storage Comment
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Target Details for NAGPA
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Target
NAGPA
(N-Acetylglucosamine-1-phosphodiester alpha-N-Acetylglucosaminidase (NAGPA))
Alternative Name
NAGPA (NAGPA Products )
Synonyms
NAGPA antibody, APAA antibody, UCE antibody, AI596180 antibody, N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase antibody, NAGPA antibody, NAEGRDRAFT_56913 antibody, Nagpa antibody
Background
Hydrolases are transported to lysosomes after binding to mannose 6-phosphate receptors in the trans-Golgi network. This gene encodes the enzyme that catalyzes the second step in the formation of the mannose 6-phosphate recognition marker on lysosomal hydrolases. Commonly known as 'uncovering enzyme' or UCE, this enzyme removes N-acetyl-D-glucosamine (GlcNAc) residues from GlcNAc-alpha-P-mannose moieties and thereby produces the recognition marker. This reaction most likely occurs in the trans-Golgi network. This enzyme functions as a homotetramer of two disulfide-linked homodimers. In addition to having an N-terminal signal peptide, the protein's C-terminus contains multiple signals for trafficking it between lysosomes, the plasma membrane, and trans-Golgi network. Alias Symbols: APAA, UCE Protein Interaction Partner: ZHX2, DEGS1, NAGPA, EPS15, AP2A1, FURIN, Protein Size: 515
Molecular Weight
53 kDa
Gene ID
51172
NCBI Accession
NM_016256 , NP_057340
UniProt
Q9UK23
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