COQ2 antibody (Middle Region)

Catalog No. ABIN2782857

Product Details anti-COQ2 Antibody

Target: COQ2 (Coenzyme Q2 Homolog, Prenyltransferase (COQ2))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Pig, Dog, Goat, Horse, Rabbit, Saccharomyces cerevisiae, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COQ2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: FSGVMWTLIY DTIYAHQDKR DDVLIGLKST ALRFGENTKP WLSGFSVAML

Predicted Reactivity: Dog: 93%, Goat: 79%, Horse: 79%, Human: 100%, Mouse: 86%, Pig: 86%, Rabbit: 93%, Rat: 86%, Yeast: 91%, Zebrafish: 86%

Characteristics: This is a rabbit polyclonal antibody against COQ2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human COQ2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 384 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-COQ2 antibody (ABIN2782857)

Sasaki, Kotoh, Watadani, Matsumoto: "New animal models reveal that coenzyme Q2 (Coq2) and placenta-specific 8 (Plac8) are candidate genes for the onset of type 2 diabetes associated with obesity in rats." in: Mammalian genome : official journal of the International Mammalian Genome Society, Vol. 26, Issue 11-12, pp. 619-29, (2015) (PubMed).

Target Details for COQ2

Target: COQ2 (Coenzyme Q2 Homolog, Prenyltransferase (COQ2))

Alternative Name: COQ2 (COQ2 Products)

Background: COQ2 catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. COQ2 mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB.CoQ (ubiquinone) serves as a redox carrier in the mitochondrial respiratory chain and is a lipid-soluble antioxidant. COQ2, or parahydroxybenzoate-polyprenyltransferase (EC 2.5.1.39), catalyzes one of the final reactions in the biosynthesis of CoQ, the prenylation of parahydroxybenzoate with an all-trans polyprenyl group (Forsgren et al., 2004 [PubMed 15153069]).[supplied by OMIM]. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-90 BC020728.1 1-90 91-96 BG699931.1 80-85 97-789 BC020728.1 97-789 790-792 BQ363759.1 169-171 793-1535 BC020728.1 793-1535 1536-1554 BC008804.2 1496-1514
Alias Symbols: CL640, FLJ26072
Protein Interaction Partner: UBC,
Protein Size: 384

Molecular Weight: 42 kDa

Gene ID: 27235

NCBI Accession: NM_015697, NP_056512

UniProt: Q96H96