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COQ2 antibody (Middle Region)

COQ2 Reactivity: Human, Mouse, Rat, Pig, Rabbit, Saccharomyces cerevisiae, Zebrafish (Danio rerio), Dog, Goat, Horse WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2782857
  • Target See all COQ2 Antibodies
    COQ2 (Coenzyme Q2 Homolog, Prenyltransferase (COQ2))
    Binding Specificity
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    Human, Mouse, Rat, Pig, Rabbit, Saccharomyces cerevisiae, Zebrafish (Danio rerio), Dog, Goat, Horse
    Host
    • 3
    • 2
    Rabbit
    Clonality
    • 3
    • 2
    Polyclonal
    Conjugate
    • 5
    This COQ2 antibody is un-conjugated
    Application
    • 4
    • 3
    Western Blotting (WB)
    Sequence
    FSGVMWTLIY DTIYAHQDKR DDVLIGLKST ALRFGENTKP WLSGFSVAML
    Predicted Reactivity
    Dog: 93%, Goat: 79%, Horse: 79%, Human: 100%, Mouse: 86%, Pig: 86%, Rabbit: 93%, Rat: 86%, Yeast: 91%, Zebrafish: 86%
    Characteristics
    This is a rabbit polyclonal antibody against COQ2. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human COQ2
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 384 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Sasaki, Kotoh, Watadani, Matsumoto: "New animal models reveal that coenzyme Q2 (Coq2) and placenta-specific 8 (Plac8) are candidate genes for the onset of type 2 diabetes associated with obesity in rats." in: Mammalian genome : official journal of the International Mammalian Genome Society, Vol. 26, Issue 11-12, pp. 619-29, (2015) (PubMed).

  • Target
    COQ2 (Coenzyme Q2 Homolog, Prenyltransferase (COQ2))
    Alternative Name
    COQ2 (COQ2 Products)
    Synonyms
    CG9613 antibody, COQ2 antibody, Dmel\\CG9613 antibody, coq2 antibody, sbo antibody, CL640 antibody, COQ10D1 antibody, MSA1 antibody, RGD1306722 antibody, zgc:162600 antibody, 2310002F18Rik antibody, Coenzyme Q biosynthesis protein 2 antibody, coenzyme Q2, polyprenyltransferase antibody, coenzyme Q2 4-hydroxybenzoate polyprenyltransferase antibody, 4-hydroxybenzoate polyprenyltransferase, mitochondrial antibody, Coq2 antibody, COQ2 antibody, coq2 antibody, coq-2 antibody
    Background
    COQ2 catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. COQ2 mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB.CoQ (ubiquinone) serves as a redox carrier in the mitochondrial respiratory chain and is a lipid-soluble antioxidant. COQ2, or parahydroxybenzoate-polyprenyltransferase (EC 2.5.1.39), catalyzes one of the final reactions in the biosynthesis of CoQ, the prenylation of parahydroxybenzoate with an all-trans polyprenyl group (Forsgren et al., 2004 [PubMed 15153069]).[supplied by OMIM]. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-90 BC020728.1 1-90 91-96 BG699931.1 80-85 97-789 BC020728.1 97-789 790-792 BQ363759.1 169-171 793-1535 BC020728.1 793-1535 1536-1554 BC008804.2 1496-1514
    Alias Symbols: CL640, FLJ26072
    Protein Interaction Partner: UBC,
    Protein Size: 384
    Molecular Weight
    42 kDa
    Gene ID
    27235
    NCBI Accession
    NM_015697, NP_056512
    UniProt
    Q96H96
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