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PCDHA4 antibody (C-Term)

PCDHA4 Reactivity: Human, Guinea Pig, Rat, Dog, Horse, Mouse, Cow WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2782799
  • Target See all PCDHA4 Antibodies
    PCDHA4 (Protocadherin alpha 4 (PCDHA4))
    Binding Specificity
    • 9
    • 8
    • 7
    • 2
    • 2
    • 1
    • 1
    C-Term
    Reactivity
    • 23
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Guinea Pig, Rat, Dog, Horse, Mouse, Cow
    Host
    • 21
    • 2
    Rabbit
    Clonality
    • 23
    Polyclonal
    Conjugate
    • 13
    • 2
    • 2
    • 2
    • 2
    • 2
    This PCDHA4 antibody is un-conjugated
    Application
    • 22
    • 13
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    SGYNAWLSYE LQPETASASI PFRVGLYTGE ISTTRALDET DAPRQRLLVL
    Predicted Reactivity
    Cow: 93%, Dog: 93%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 93%, Rat: 93%
    Characteristics
    This is a rabbit polyclonal antibody against PCDHA4. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the C terminal region of human PCDHA4
    Top Product
    Discover our top product PCDHA4 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 947 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    PCDHA4 (Protocadherin alpha 4 (PCDHA4))
    Alternative Name
    PCDHA4 (PCDHA4 Products)
    Synonyms
    CNR1 antibody, CNRN1 antibody, CRNR1 antibody, PCDH-ALPHA4 antibody, Cnr1 antibody, Crnr1 antibody, R75250 antibody, PCDHA4 antibody, CNRv4 antibody, Pcdha4 antibody, protocadherin alpha 4 antibody, protocadherin alpha-4 antibody, PCDHA4 antibody, Pcdha4 antibody, LOC100713594 antibody, LOC100629843 antibody
    Background
    The gene encoding PCDHA4 is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. PCDHA4 is a single-pass type I membrane protein. It contains 6 cadherin domains. PCDHA4 is a potential calcium-dependent cell-adhesion protein. It may be involved in the establishment and maintenance of specific neuronal connections in the brain.This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.
    Alias Symbols: CNR1, CNRN1, CRNR1, MGC138307, MGC142169, PCDH-ALPHA4
    Protein Interaction Partner: SGTA, LRIF1, CCDC90B, RBM48, IGSF21, SETDB1, C14orf1, UNC119, GDF9, RELN, TLE1, TP53, GAPDH, EEF1A1, APLP1,
    Protein Size: 947
    Molecular Weight
    99 kDa
    Gene ID
    56144
    NCBI Accession
    NM_018907, NP_061730
    UniProt
    Q9UN74
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