PCDHA4 antibody (C-Term)

Catalog No. ABIN2782799

Product Details anti-PCDHA4 Antibody

Target: PCDHA4 (Protocadherin alpha 4 (PCDHA4))

Binding Specificity: C-Term

Reactivity: Human, Guinea Pig, Rat, Cow, Dog, Horse, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PCDHA4 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: SGYNAWLSYE LQPETASASI PFRVGLYTGE ISTTRALDET DAPRQRLLVL

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 93%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against PCDHA4. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human PCDHA4

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 947 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PCDHA4

Target: PCDHA4 (Protocadherin alpha 4 (PCDHA4))

Alternative Name: PCDHA4 (PCDHA4 Products)

Synonyms: CNR1 antibody, CNRN1 antibody, CRNR1 antibody, PCDH-ALPHA4 antibody, Cnr1 antibody, Crnr1 antibody, R75250 antibody, PCDHA4 antibody, CNRv4 antibody, Pcdha4 antibody, protocadherin alpha 4 antibody, protocadherin alpha-4 antibody, PCDHA4 antibody, Pcdha4 antibody, LOC100713594 antibody, LOC100629843 antibody

Background: The gene encoding PCDHA4 is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. PCDHA4 is a single-pass type I membrane protein. It contains 6 cadherin domains. PCDHA4 is a potential calcium-dependent cell-adhesion protein. It may be involved in the establishment and maintenance of specific neuronal connections in the brain.This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.
Alias Symbols: CNR1, CNRN1, CRNR1, MGC138307, MGC142169, PCDH-ALPHA4
Protein Interaction Partner: SGTA, LRIF1, CCDC90B, RBM48, IGSF21, SETDB1, C14orf1, UNC119, GDF9, RELN, TLE1, TP53, GAPDH, EEF1A1, APLP1,
Protein Size: 947

Molecular Weight: 99 kDa

Gene ID: 56144

NCBI Accession: NM_018907, NP_061730

UniProt: Q9UN74