ALDH6A1 antibody (Middle Region)

Catalog No. ABIN2782682

Product Details anti-ALDH6A1 Antibody

Target: ALDH6A1 (Aldehyde Dehydrogenase 6 Family, Member A1 (ALDH6A1))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Dog, Cow, Pig, Rabbit, Horse, Guinea Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ALDH6A1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: GQVGVNVPIP VPLPMFSFTG SRSSFRGDTN FYGKQGIQFY TQLKTITSQW

Predicted Reactivity: Cow: 93%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against ALDH6A1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ALDH6A1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 535 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-ALDH6A1 antibody (ABIN2782682)

Kuiper, Williams, Distl, Drögemüller: "Assignment of the PAX6 gene to bovine chromosome 15q25-->q27 by fluorescence in situ hybridization and confirmation by radiation hybrid mapping." in: Cytogenetic and genome research, Vol. 109, Issue 4, pp. 533, (2005) (PubMed).

Target Details for ALDH6A1

Target: ALDH6A1 (Aldehyde Dehydrogenase 6 Family, Member A1 (ALDH6A1))

Alternative Name: ALDH6A1 (ALDH6A1 Products)

Synonyms: MMSADHA antibody, MMSDH antibody, Mmsdh antibody, cb850 antibody, wu:fb03a04 antibody, zgc:92082 antibody, 1110038I05Rik antibody, AI314632 antibody, aldehyde dehydrogenase 6 family member A1 antibody, aldehyde dehydrogenase 6 family, member A1 antibody, aldehyde dehydrogenase 6 family member A1 L homeolog antibody, methylmalonic acid semialdehyde dehydrogenase antibody, methylmalonate-semialdehyde dehydrogenase (CoA acylating) antibody, aldehyde dehydrogenase family 6, subfamily A1 antibody, ALDH6A1 antibody, Aldh6a1 antibody, aldh6a1.L antibody, CCNA_02357 antibody, aldh6a1 antibody, VAA_RS07845 antibody

Background: ALDH6A1 plays a role in valine and pyrimidine metabolism. ALDH6A1 binds fatty acyl-CoA. This protein belongs to the aldehyde dehydrogenases family of proteins. This enzyme plays a role in the valine and pyrimidine catabolic pathways. The product of this gene, a mitochondrial methylmalonate semialdehyde dehydrogenase, catalyzes the irreversible oxidative decarboxylation of malonate and methylmalonate semialdehydes to acetyl- and propionyl-CoA. Methylmalonate semialdehyde dehydrogenase deficiency is characterized by elevated beta-alanine, 3-hydroxypropionic acid, and both isomers of 3-amino and 3-hydroxyisobutyric acids in urine organic acids.
Alias Symbols: MGC40271, MMSADHA, MMSDH
Protein Interaction Partner: UBC, LMO2,
Protein Size: 535

Molecular Weight: 58 kDa

Gene ID: 4329

NCBI Accession: NM_005589, NP_005580

UniProt: Q02252

Pathways: Brown Fat Cell Differentiation