DGCR2 antibody (Middle Region)

Catalog No. ABIN2782668

Product Details anti-DGCR2 Antibody

Target: DGCR2 (DGS2) (DiGeorge Syndrome Chromosome Region-2 (DGS2))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Cow, Guinea Pig, Dog, Horse, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DGCR2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: AESCYEKSSF LCKRSQTCVD IKDNVVDEGF YFTPKGDDPC LSCTCHGGEP

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%

Characteristics: This is a rabbit polyclonal antibody against DGCR2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human DGCR2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 550 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for DGCR2

Target: DGCR2 (DGS2) (DiGeorge Syndrome Chromosome Region-2 (DGS2))

Alternative Name: DGCR2 (DGS2 Products)

Synonyms: DGS-C antibody, IDD antibody, LAN antibody, SEZ-12 antibody, CIDD antibody, 9930034O06Rik antibody, Dgsc antibody, Idd antibody, Lan antibody, Sez12 antibody, mKIAA0163 antibody, zgc:91974 antibody, DiGeorge syndrome critical region gene 2 antibody, DiGeorge syndrome critical region gene 2 S homeolog antibody, DGCR2 antibody, Dgcr2 antibody, dgcr2 antibody, dgcr2.S antibody

Background: Deletions of the 22q11.2 have been associated with a wide range of developmental defects classified under the acronym CATCH 22. The DGCR2 is a novel putative adhesion receptor protein, which could play a role in neural crest cells migration, a process which has been proposed to be altered in DiGeorge syndrome. Deletions of the 22q11.2 have been associated with a wide range of developmental defects (notably DiGeorge syndrome, velocardiofacial syndrome, conotruncal anomaly face syndrome and isolated conotruncal cardiac defects) classified under the acronym CATCH 22. The DGCR2 gene encodes a novel putative adhesion receptor protein, which could play a role in neural crest cells migration, a process which has been proposed to be altered in DiGeorge syndrome.
Alias Symbols: DGS-C, DKFZp686I1730, IDD, KIAA0163, LAN, SEZ-12
Protein Interaction Partner: HNRNPD, SMURF2, DDIT3,
Protein Size: 550

Molecular Weight: 61 kDa

Gene ID: 9993

NCBI Accession: NM_005137, NP_005128

UniProt: P98153