HRK antibody (N-Term)

Catalog No. ABIN2782598

Product Details anti-HRK Antibody

Target: HRK (Harakiri, BCL2 Interacting Protein (Contains Only BH3 Domain) (HRK))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Rabbit, Cow, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HRK antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: MCPCPLHRGR GPPAVCACSA GRLGLRSSAA QLTAARLKAL GDELHQRTMW

Predicted Reactivity: Cow: 100%, Dog: 100%, Human: 100%, Mouse: 83%, Rabbit: 100%, Rat: 83%

Characteristics: This is a rabbit polyclonal antibody against HRK. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human HRK

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 91 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-HRK antibody (ABIN2782598)

Lucas, Milani, Butterworth, Carmell, Scott, Clark, Cohen, Varadarajan: "High CIP2A levels correlate with an antiapoptotic phenotype that can be overcome by targeting BCL-XL in chronic myeloid leukemia." in: Leukemia, Vol. 30, Issue 6, pp. 1273-81, (2016) (PubMed).

Target Details for HRK

Target: HRK (Harakiri, BCL2 Interacting Protein (Contains Only BH3 Domain) (HRK))

Alternative Name: HRK (HRK Products)

Synonyms: DP5 antibody, HARAKIRI antibody, AI838259 antibody, Bid3 antibody, harakiri antibody, Dp5 antibody, harakiri, BCL2 interacting protein antibody, harakiri, BCL2 interacting protein (contains only BH3 domain) antibody, HRK antibody, Hrk antibody

Background: Activator of apoptosis Hrk regulates apoptosis through interaction with death-repressor proteins Bcl-2 and Bcl-X(L). The HRK protein lacks significant homology to other BCL2 family members except for an 8-amino acid region that was similar to the BCL2 hom
Alias Symbols: DP5, HARAKIRI
Protein Interaction Partner: BCL2L1, ELAVL1, BAD, BCL2L2, C1QBP, BCL2A1, BCL2, MCL1, BNC1,
Protein Size: 91

Molecular Weight: 10 kDa

Gene ID: 8739

NCBI Accession: NM_003806, NP_003797

UniProt: O00198