CDT1 antibody (C-Term)

Catalog No. ABIN2782592

Product Details anti-CDT1 Antibody

Target: CDT1 (Chromatin Licensing and DNA Replication Factor 1 (CDT1))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Pig, Rabbit, Saccharomyces cerevisiae, Cow, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDT1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: PATPPATPPA ASPSALKGVS QDLLERIRAK EAQKQLAQMT RCPEQEQRLQ

Predicted Reactivity: Cow: 93%, Dog: 77%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%, Yeast: 85%

Characteristics: This is a rabbit polyclonal antibody against CDT1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human CDT1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 546 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CDT1

Target: CDT1 (Chromatin Licensing and DNA Replication Factor 1 (CDT1))

Alternative Name: CDT1 (CDT1 Products)

Synonyms: CDT1 antibody, fc37h07 antibody, im:7158083 antibody, wu:fc37h07 antibody, wu:fi38h09 antibody, xcdt1 antibody, DUP antibody, RIS2 antibody, 2610318F11Rik antibody, AW545653 antibody, C76791 antibody, Ris2 antibody, dup antibody, ris2 antibody, chromatin licensing and DNA replication factor 1 antibody, chromatin licensing and DNA replication factor 1 L homeolog antibody, CDT1 antibody, cdt1 antibody, Cdt1 antibody, cdt1.L antibody

Background: CDT1 cooperates with CDC6 to promote the loading of the mini-chromosome maintenance complex onto chromatin to form the pre-replication complex necessary to initiate DNA replication. It binds DNA in a sequence-, strand-, and conformation-independent manner and is a potential oncogene.
Alias Symbols: DUP, RIS2
Protein Interaction Partner: FBXO31, SKP1, RBX1, CUL1, DTL, PCNA, HECW2, CDK2, CDC6, CDC5L, ORC2, ORC1, GMNN, DGCR8, UBC, SKP2, CDK1, CCNB1, CCNA2, FOXO3, DDB1, COPS5, CUL4A, CUL4B, SMARCA5, MCM6, MAPK8, MAPK1, HDAC11, KAT7, CCNA1, DDB2, CDK4, CCNE1, TP63, TP73, EP300, KAT2B, CDT1, U
Protein Size: 546

Molecular Weight: 60 kDa

Gene ID: 81620

NCBI Accession: NM_030928, NP_112190

UniProt: Q9H211

Pathways: MAPK Signaling, Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA