SWAP70 antibody (N-Term)

Catalog No. ABIN2782542

Product Details anti-SWAP70 Antibody

Target: SWAP70 (SWAP Switching B-Cell Complex 70kDa Subunit (SWAP70))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Rabbit, Zebrafish (Danio rerio), Cow, Dog, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SWAP70 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: ALEEHFRDDD EGPVSNQGYM PYLNRFILEK VQDNFDKIEF NRMCWTLCVK

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against SWAP70. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SWAP70

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 585 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-SWAP70 antibody (ABIN2782542)

Rosati, Krebs, Liu: "Emissions from cooking microwave popcorn." in: Critical reviews in food science and nutrition, Vol. 47, Issue 8, pp. 701-9, (2007) (PubMed).

Target Details for SWAP70

Target: SWAP70 (SWAP Switching B-Cell Complex 70kDa Subunit (SWAP70))

Alternative Name: SWAP70 (SWAP70 Products)

Synonyms: SWAP-70 antibody, 70kDa antibody, AV235546 antibody, HSPC321 antibody, swap70b antibody, zgc:63599 antibody, switching B-cell complex subunit SWAP70 antibody, SWA-70 protein antibody, SWAP switching B-cell complex 70 antibody, SWAP switching B-cell complex 70kDa subunit antibody, switching B-cell complex subunit SWAP70a antibody, SWAP70 antibody, Swap70 antibody, swap70 antibody, swap70a antibody

Background: Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. SWAP70 also mediates signaling of membrane ruffling. It regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion.
Alias Symbols: FLJ39540, HSPC321, KIAA0640, SWAP-70
Protein Interaction Partner: ZBTB5, RAPGEF4, UBC, CORO1B, ASUN, OTUD6B, JMJD6, GANAB, PACSIN2, FAF1, PAICS, FARSB, ZRANB2, RANBP3, CUL1, SUPT5H, SET, PPP2R5C, PLOD2, OSBP, GART, XRCC6, CRMP1, ATP6V1B2, C18orf8, CELSR3, IGHG1, PARP1, NPM1, NCL,
Protein Size: 585

Molecular Weight: 69 kDa

Gene ID: 23075

NCBI Accession: NM_015055, NP_055870

UniProt: Q9UH65

Pathways: Production of Molecular Mediator of Immune Response