PDSS1 antibody (Middle Region)

Catalog No. ABIN2782534

Product Details anti-PDSS1 Antibody

Target: PDSS1 (Prenyl (Decaprenyl) Diphosphate Synthase, Subunit 1 (PDSS1))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Cow, Dog, Guinea Pig, Rabbit, Horse, Rat, Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDSS1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: GEFLQLGSKE NENERFAHYL EKTFKKTASL IANSCKAVSV LGCPDPVVHE

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against PDSS1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PDSS1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 415 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PDSS1

Target: PDSS1 (Prenyl (Decaprenyl) Diphosphate Synthase, Subunit 1 (PDSS1))

Alternative Name: PDSS1 (PDSS1 Products)

Synonyms: COQ1 antibody, COQ10D2 antibody, DPS antibody, RP13-16H11.3 antibody, SPS antibody, TPRT antibody, TPT antibody, TPT 1 antibody, hDPS1 antibody, 2610203G20Rik antibody, 2700031G06Rik antibody, Tprt antibody, mDLP1 antibody, mSPS1 antibody, tprt antibody, wu:fc11f12 antibody, wu:fd05d05 antibody, zgc:112058 antibody, T30F21.15 antibody, T30F21_15 antibody, solanesyl diphosphate synthase 1 antibody, decaprenyl diphosphate synthase subunit 1 antibody, prenyl (solanesyl) diphosphate synthase, subunit 1 antibody, prenyl (decaprenyl) diphosphate synthase, subunit 1 antibody, solanesyl diphosphate synthase 1 antibody, PDSS1 antibody, Pdss1 antibody, pdss1 antibody, SPS1 antibody

Background: PDSS1 is an enzyme that elongates the prenyl side-chain of coenzyme Q, or ubiquinone, one of the key elements in the respiratory chain. PDSS1 catalyzes the formation of all trans-polyprenyl pyrophosphates from isopentyl diphosphate in the assembly of polyisoprenoid side chains, the first step in coenzyme Q biosynthesis. The protein may be peripherally associated with the inner mitochondrial membrane, though no transit peptide has been definitively identified to date. Defects in PDSS1 gene are a cause of coenzyme Q10 deficiency.The protein encoded by this gene is an enzyme that elongates the prenyl side-chain of coenzyme Q, or ubiquinone, one of the key elements in the respiratory chain. The gene product catalyzes the formation of all trans-polyprenyl pyrophosphates from isopentyl diphosphate in the assembly of polyisoprenoid side chains, the first step in coenzyme Q biosynthesis. The protein may be peripherally associated with the inner mitochondrial membrane, though no transit peptide has been definitively identified to date. Defects in this gene are a cause of coenzyme Q10 deficiency.
Alias Symbols: COQ1, MGC70953, RP13-16H11.3, TPRT, TPT, hDPS1, DPS, SPS, TPT 1
Protein Interaction Partner: UBC,
Protein Size: 415

Molecular Weight: 46 kDa

Gene ID: 23590

NCBI Accession: NM_014317, NP_055132

UniProt: Q5T2R2