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VARS antibody (Middle Region)

VARS Reactivity: Human, Mouse, Rat, Rabbit, Cow, Horse, Dog, Guinea Pig, Zebrafish (Danio rerio), Saccharomyces cerevisiae WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2782517
  • Target See all VARS Antibodies
    VARS (Valyl-tRNA Synthetase (VARS))
    Binding Specificity
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    • 21
    • 10
    • 6
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    Human, Mouse, Rat, Rabbit, Cow, Horse, Dog, Guinea Pig, Zebrafish (Danio rerio), Saccharomyces cerevisiae
    Host
    • 19
    • 3
    Rabbit
    Clonality
    • 20
    • 2
    Polyclonal
    Conjugate
    • 22
    This VARS antibody is un-conjugated
    Application
    • 20
    • 8
    • 6
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequence
    VFDEFVDMDF GTGAVKITPA HDQNDYEVGQ RHGLEAISIM DSRGALINVP
    Predicted Reactivity
    Cow: 100%, Dog: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 86%, Zebrafish: 86%
    Characteristics
    This is a rabbit polyclonal antibody against VARS. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human VARS
    Top Product
    Discover our top product VARS Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 1264 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Duarte, Videira: "Defective valyl-tRNA synthetase hampers the mitochondrial respiratory chain in Neurospora crassa." in: The Biochemical journal, Vol. 448, Issue 3, pp. 297-306, (2012) (PubMed).

    Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: "Large-scale mapping of human protein-protein interactions by mass spectrometry. ..." in: Molecular systems biology, Vol. 3, pp. 89, (2007) (PubMed).

  • Target
    VARS (Valyl-tRNA Synthetase (VARS))
    Alternative Name
    VARS (VARS Products)
    Background
    Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. VARS belongs to class-I aminoacyl-tRNA synthetase family and is located in the class III region of the major histocompatibility complex.Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. The protein encoded by this gene belongs to class-I aminoacyl-tRNA synthetase family and is located in the class III region of the major histocompatibility complex. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
    Alias Symbols: G7A, VARS2, VARS1
    Protein Interaction Partner: CALCOCO2, SUMO2, SART3, STAU1, UBC, EED, CCT4, KNTC1, AIMP1, CCT3, QARS, EEF1G, EEF1D, EEF1B2, FBXO6, YWHAQ, MAPK11, VCAM1, ITGA4, FN1, LARS, CAD, UBD, SHC1, CUL3, CDK2, CHD7, CACNA1A, ATG101, OTUD5, DMWD, EEF1A1, EEF1A2, TRAF6, TFE3, HLA-B, EPB41,
    Protein Size: 1264
    Molecular Weight
    140 kDa
    Gene ID
    7407
    NCBI Accession
    NM_006295, NP_006286
    UniProt
    P26640
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