PDK3 antibody (N-Term)

Catalog No. ABIN2782501

Product Details anti-PDK3 Antibody

Target: PDK3 (Pyruvate Dehydrogenase Kinase, Isozyme 3 (PDK3))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Cow, Guinea Pig, Zebrafish (Danio rerio), Dog, Horse, Rabbit, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDK3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: RPSVGLVQSW YMQSFLELLE YENKSPEDPQ VLDNFLQVLI KVRNRHNDVV

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 85%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 75%

Characteristics: This is a rabbit polyclonal antibody against PDK3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PDK3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 406 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PDK3

Target: PDK3 (Pyruvate Dehydrogenase Kinase, Isozyme 3 (PDK3))

Alternative Name: PDK3 (PDK3 Products)

Synonyms: pdk3 antibody, PDK3 antibody, 2610001M10Rik antibody, AI035637 antibody, zgc:158702 antibody, pyruvate dehydrogenase kinase 3 antibody, pyruvate dehydrogenase kinase, isozyme 3a antibody, pyruvate dehydrogenase kinase, isoenzyme 3 antibody, fragile site, 5-azacytidine type, common, fra(1)(q12) antibody, pyruvate dehydrogenase kinase, isozyme 3b antibody, PDK3 antibody, Pdk3 antibody, pdk3a antibody, pdk3 antibody, FRA1J antibody, pdk3b antibody

Background: PDK3 belongs to the PDK/BCKDK protein kinase family. It contains 1 histidine kinase domain. PDK3 inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism.
Alias Symbols: -
Protein Interaction Partner: APP, UBD, UBC, ICT1, EGFR, DLAT, PDHA1,
Protein Size: 406

Molecular Weight: 47 kDa

Gene ID: 5165

NCBI Accession: NM_005391, NP_005382

UniProt: Q15120

Pathways: PI3K-Akt Signaling, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, Warburg Effect