HAL antibody (C-Term)

Catalog No. ABIN2782321

Product Details anti-HAL Antibody

Target: HAL (Histidine Ammonia-Lyase (HAL))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Zebrafish (Danio rerio), Rabbit, Cow, Dog, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HAL antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: EAAHRLLLEQ KVWEVAAPYI EKYRMEHIPE SRPLSPTAFS LQFLHKKSTK

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 86%

Characteristics: This is a rabbit polyclonal antibody against HAL. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human HAL

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 657 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-HAL antibody (ABIN2782321)

Hu, Lausted, Yoo, Yan, Brightman, Chen, Wang, Bu, Hood: "Quantitative liver-specific protein fingerprint in blood: a signature for hepatotoxicity." in: Theranostics, Vol. 4, Issue 2, pp. 215-28, (2014) (PubMed).

Alemán, Ortíz, Langley, Tovar, Torres: "Regulation by glucagon of the rat histidase gene promoter in cultured rat hepatocytes and human hepatoblastoma cells." in: American journal of physiology. Endocrinology and metabolism, Vol. 289, Issue 1, pp. E172-9, (2005) (PubMed).

Target Details for HAL

Target: HAL (Histidine Ammonia-Lyase (HAL))

Alternative Name: HAL (HAL Products)

Synonyms: HIS antibody, HSTD antibody, hal antibody, hstd antibody, xhal antibody, HAL antibody, BA3712 antibody, DDBDRAFT_0187742 antibody, DDBDRAFT_0231727 antibody, DDB_0187742 antibody, DDB_0231727 antibody, zgc:136980 antibody, his antibody, Hsd antibody, histidase antibody, histidine ammonia-lyase antibody, histidine ammonia-lyase, gene 1 L homeolog antibody, histidine ammonia-lyase HutH antibody, histidine ammonia-lyase, gene 1 antibody, histidine ammonia lyase antibody, HAL antibody, hal.1.L antibody, hutH antibody, Tc00.1047053506247.220 antibody, Plav_1493 antibody, hal antibody, hal.1 antibody, Hal antibody

Background: HAL is a cytosolic enzyme catalyzing the first reaction in histidine catabolism, the nonoxidative deamination of L-histidine to trans-urocanic acid. HAL defects cause histidinemia which is characterized by increased histidine and histamine and decreased urocanic acid in body fluidsHistidine ammonia-lyase is a cytosolic enzyme catalyzing the first reaction in histidine catabolism, the nonoxidative deamination of L-histidine to trans-urocanic acid. Histidine ammonia-lyase defects cause histidinemia which is characterized by increased histidine and histamine and decreased urocanic acid in body fluids.
Alias Symbols: HIS, HSTD
Protein Interaction Partner: UBC,
Protein Size: 657

Molecular Weight: 72 kDa

Gene ID: 3034

NCBI Accession: NM_002108, NP_002099

UniProt: P42357