IGFBP4 antibody (Middle Region)

Catalog No. ABIN2782316

Product Details anti-IGFBP4 Antibody

Target: IGFBP4 (Insulin-Like Growth Factor Binding Protein 4 (IGFBP4))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Rabbit, Sheep, Goat, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IGFBP4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: RALERLAASQ SRTHEDLYII PIPNCDRNGN FHPKQCHPAL DGQRGKCWCV

Predicted Reactivity: Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%

Characteristics: This is a rabbit polyclonal antibody against IGFBP4. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human IGFBP4

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 258 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-IGFBP4 antibody (ABIN2782316)

Shi, Chiang, Mistretta, Major, Mori-Akiyama: "SOX9 directly regulates IGFBP-4 in the intestinal epithelium." in: American journal of physiology. Gastrointestinal and liver physiology, Vol. 305, Issue 1, pp. G74-83, (2013) (PubMed).

Target Details for IGFBP4

Target: IGFBP4 (Insulin-Like Growth Factor Binding Protein 4 (IGFBP4))

Alternative Name: IGFBP4 (IGFBP4 Products)

Synonyms: IGFBP4 antibody, igfbp4 antibody, BP-4 antibody, HT29-IGFBP antibody, IBP4 antibody, IGFBP-4 antibody, AI875747 antibody, Deb2 antibody, IGF-BP4 antibody, IBP-4 antibody, insulin like growth factor binding protein 4 antibody, insulin-like growth factor-binding protein 4 antibody, insulin-like growth factor binding protein 4 antibody, IGFBP4 antibody, LOC100136305 antibody, LOC100194498 antibody, igfbp4 antibody, Igfbp4 antibody

Background: IGFBP4 is a member of the insulin-like growth factor binding protein (IGFBP) family. IGFBP4 is a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors.This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: BP-4, HT29-IGFBP, IBP4, IGFBP-4
Protein Interaction Partner: KDM1A, SUV39H1, Hk3, Hk2, TF, PAPPA, IGF2, IGF1, CTSD,
Protein Size: 258

Molecular Weight: 28 kDa

Gene ID: 3487

NCBI Accession: NM_001552, NP_001543

UniProt: P22692

Pathways: WNT Signaling, Myometrial Relaxation and Contraction, Regulation of Carbohydrate Metabolic Process