SMPD2 antibody (N-Term)

Catalog No. ABIN2782209

Product Details anti-SMPD2 Antibody

Target: SMPD2 (Sphingomyelin phosphodiesterase 2, Neutral Membrane (Neutral Sphingomyelinase) (SMPD2))

Binding Specificity: N-Term

Reactivity: Human, Rat, Mouse, Dog, Cow, Horse, Guinea Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMPD2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: RQKLSPTYPA AHHFRSGIIG SGLCVFSKHP IQELTQHIYT LNGYPYMIHH

Predicted Reactivity: Cow: 79%, Dog: 86%, Guinea Pig: 79%, Horse: 86%, Human: 100%, Mouse: 77%, Rabbit: 79%, Rat: 79%

Characteristics: This is a rabbit polyclonal antibody against SMPD2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SMPD2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 423 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-SMPD2 antibody (ABIN2782209)

Lazrek, Goffard, Schanen, Karquel, Bocket, Lion, Devaux, Hedouin, Gosset, Hober: "Detection of hepatitis C virus antibodies and RNA among medicolegal autopsy cases in Northern France." in: Diagnostic microbiology and infectious disease, Vol. 55, Issue 1, pp. 55-8, (2006) (PubMed).

Target Details for SMPD2

Target: SMPD2 (Sphingomyelin phosphodiesterase 2, Neutral Membrane (Neutral Sphingomyelinase) (SMPD2))

Alternative Name: SMPD2 (SMPD2 Products)

Synonyms: SMPD2 antibody, NSMase antibody, isc1 antibody, nsmase antibody, nsmase1 antibody, AW108287 antibody, nSMase antibody, nSMase1 antibody, ISC1 antibody, NSMASE antibody, NSMASE1 antibody, sphingomyelin phosphodiesterase 2 antibody, sphingomyelin phosphodiesterase 2a, neutral membrane (neutral sphingomyelinase) antibody, sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) antibody, sphingomyelin phosphodiesterase 2, neutral antibody, SMPD2 antibody, smpd2a antibody, smpd2 antibody, Smpd2 antibody

Background: SMPD2 converts sphingomyelin to ceramide. Hydrolyze 1-acyl-2-lyso-sn-glycero-3-phosphocholine (lyso-PC) and 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine (lyso-platelet-activating factor). The physiological substrate seems to be Lyso-PAF.
Alias Symbols: NSMASE, ISC1, NSMASE1
Protein Interaction Partner: UBC, PIK3CG,
Protein Size: 423

Molecular Weight: 48 kDa

Gene ID: 6610

NCBI Accession: NM_003080, NP_003071

UniProt: O60906

Pathways: Neurotrophin Signaling Pathway