PTPN2 antibody (N-Term)
-
- Target See all PTPN2 Antibodies
- PTPN2 (Protein tyrosine Phosphatase, Non-Receptor Type 2 (PTPN2))
-
Binding Specificity
- N-Term
-
Reactivity
- Human, Rat, Mouse, Rabbit, Guinea Pig, Horse, Dog, Cow, Zebrafish (Danio rerio), Saccharomyces cerevisiae
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- This PTPN2 antibody is un-conjugated
-
Application
- Western Blotting (WB)
- Sequence
- LEIRNESHDY PHRVAKFPEN RNRNRYRDVS PYDHSRVKLQ NAENDYINAS
- Predicted Reactivity
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 90%, Zebrafish: 93%
- Characteristics
- This is a rabbit polyclonal antibody against PTPN2. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Protein A purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human PTPN2
- Top Product
- Discover our top product PTPN2 Primary Antibody
-
-
- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
-
Antigen size: 353 AA
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
-
- Target
- PTPN2 (Protein tyrosine Phosphatase, Non-Receptor Type 2 (PTPN2))
- Alternative Name
- PTPN2 (PTPN2 Products)
- Synonyms
- PTN2 antibody, PTPT antibody, TC-PTP antibody, TCELLPTP antibody, TCPTP antibody, AI325124 antibody, Ptpt antibody, PTP-1B antibody, cb806 antibody, ptpn2 antibody, ptpn2l antibody, wu:fc10h07 antibody, zgc:55339 antibody, zgc:76973 antibody, hm:zeh1546 antibody, zgc:63623 antibody, ptn2 antibody, ptpt antibody, tc-ptp antibody, tcellptp antibody, tcptp antibody, protein tyrosine phosphatase, non-receptor type 2 antibody, protein tyrosine phosphatase, non-receptor type 2 S homeolog antibody, protein tyrosine phosphatase, non-receptor type 2, b antibody, protein tyrosine phosphatase, non-receptor type 2, a antibody, protein tyrosine phosphatase, non-receptor type 2 L homeolog antibody, PTPN2 antibody, Ptpn2 antibody, ptpn2.S antibody, ptpn2b antibody, ptpn2a antibody, ptpn2.L antibody
- Background
-
PTPN2 is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling.The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Three alternatively spliced variants of this gene, which encode isoforms differing at their extreme C-termini, have been described. The different C-termini are thought to determine the substrate specificity, as well as the cellular localization of the isoforms. Two highly related but distinctly processed pseudogenes that localize to distinct chromosomes have been reported.
Alias Symbols: PTPT, TC-PTP, TCELLPTP, TCPTP, PTN2
Protein Interaction Partner: UBC, BAG3, STAT1, STAT6, KATNB1, HSPD1, TRAF2, SRC, GHR, UCHL5, FKBP4, STAT5B, KPNB1, STAT5A, SHC1, JAK3, ITGA1, PDGFRB, JAK1, INSR, EGFR, CDK5, CDK2, CDK1, STAT3, SFN,
Protein Size: 353 - Molecular Weight
- 39 kDa
- Gene ID
- 5771
- NCBI Accession
- NM_080423, NP_536348
- UniProt
- Q96AU5
- Pathways
- EGFR Signaling Pathway, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling
-