JAG2 antibody (N-Term)

Catalog No. ABIN2782165

Product Details anti-JAG2 Antibody

Target: JAG2 (Jagged 2 (JAG2))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This JAG2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: RAQGRGRLPR RLLLLLALWV QAARPMGYFE LQLSALRNVN GELLSGACCD

Predicted Reactivity: Human: 100%, Mouse: 100%, Pig: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against JAG2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human JAG2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1238 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-JAG2 antibody (ABIN2782165)

Passos Gregorio, Gattaz, Tavares, Kieling, Timm, Wang, Berg Rasmussen, Werge, Dias-Neto: "Analysis of coding-polymorphisms in NOTCH-related genes reveals NUMBL poly-glutamine repeat to be associated with schizophrenia in Brazilian and Danish subjects." in: Schizophrenia research, Vol. 88, Issue 1-3, pp. 275-82, (2006) (PubMed).

Target Details for JAG2

Target: JAG2 (Jagged 2 (JAG2))

Alternative Name: JAG2 (JAG2 Products)

Synonyms: D12Ggc2e antibody, Serh antibody, mJagged2-1 antibody, sm antibody, HJ2 antibody, SER2 antibody, jag2 antibody, serB antibody, zgc:152855 antibody, jagged 2 antibody, jagged 2b antibody, JAG2 antibody, jag2 antibody, Jag2 antibody, jag2b antibody

Background: The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch protein family are transmembrane receptors that are critical for various cell fate decisions. JAG2 is one of several ligands that activate Notch and related receptors. The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: HJ2, SER2
Protein Interaction Partner: GFI1B, ATN1, ATXN7, CACNA1A, MIB2, NOTCH3, NOTCH2, NOTCH1,
Protein Size: 1238

Molecular Weight: 130 kDa

Gene ID: 3714

NCBI Accession: NM_002226, NP_002217

UniProt: Q9Y219

Pathways: Notch Signaling, Sensory Perception of Sound