HMOX1 antibody (N-Term)

Catalog No. ABIN2782158

Product Details anti-HMOX1 Antibody

Target: HMOX1 (Heme Oxygenase (Decycling) 1 (HMOX1))

Binding Specificity: N-Term

Reactivity: Human, Rat, Mouse, Pig, Dog, Cow, Guinea Pig, Rabbit, Goat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HMOX1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: ERPQPDSMPQ DLSEALKEAT KEVHTQAENA EFMRNFQKGQ VTRDGFKLVM

Predicted Reactivity: Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against HMOX1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human HMOX1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 288 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-HMOX1 antibody (ABIN2782158)

Kawahara, Gasperini, Myers, Widrick, Eran, Serafini, Alexander, Pletcher, Morris, Kunkel: "Dystrophic muscle improvement in zebrafish via increased heme oxygenase signaling." in: Human molecular genetics, Vol. 23, Issue 7, pp. 1869-78, (2014) (PubMed).

Hausmann, Paul, Kellermeier, Frey, Schölmerich, Falk, Menzel, Fried, Herfarth, Rogler: "(GT)N dinucleotide repeat polymorphism of haem oxygenase-1 promotor region is not associated with inflammatory bowel disease risk or disease course." in: Clinical and experimental immunology, Vol. 153, Issue 1, pp. 81-5, (2008) (PubMed).

Target Details for HMOX1

Target: HMOX1 (Heme Oxygenase (Decycling) 1 (HMOX1))

Alternative Name: HMOX1 (HMOX1 Products)

Background: HMOX1 belongs to the heme oxygenase family. Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2.
Alias Symbols: HO-1, HSP32, bK286B10
Protein Interaction Partner: CCDC155, UBC, TUT1, CPSF1, ASL, POT1, TERF1, ELAVL1, HMX1, BLVRB, AKT1, NOS1, HMOX1, POR, UFD1L, PSMD2,
Protein Size: 288

Molecular Weight: 33 kDa

Gene ID: 3162

NCBI Accession: NM_002133, NP_002124

UniProt: P09601

Pathways: Transition Metal Ion Homeostasis, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, SARS-CoV-2 Protein Interactome