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GNS antibody (C-Term)

GNS Reactivity: Human, Mouse, Rat, Horse, Rabbit, Cow, Goat, Guinea Pig, Dog, Zebrafish (Danio rerio) WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2782155
  • Target See all GNS Antibodies
    GNS (Glucosamine (N-Acetyl)-6-Sulfatase (GNS))
    Binding Specificity
    • 15
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 32
    • 7
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Mouse, Rat, Horse, Rabbit, Cow, Goat, Guinea Pig, Dog, Zebrafish (Danio rerio)
    Host
    • 29
    • 2
    • 1
    Rabbit
    Clonality
    • 32
    Polyclonal
    Conjugate
    • 18
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This GNS antibody is un-conjugated
    Application
    • 16
    • 13
    • 13
    • 10
    • 5
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequence
    PILRGASNLT WRSDVLVEYQ GEGRNVTDPT CPSLSPGVSQ CFPDCVCEDA
    Predicted Reactivity
    Cow: 100%, Dog: 93%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 85%
    Characteristics
    This is a rabbit polyclonal antibody against GNS. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the C terminal region of human GNS
    Top Product
    Discover our top product GNS Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 552 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    GNS (Glucosamine (N-Acetyl)-6-Sulfatase (GNS))
    Alternative Name
    GNS (GNS Products)
    Synonyms
    G6S antibody, 2610016K11Rik antibody, AU042285 antibody, C87209 antibody, N28088 antibody, NV14559 antibody, N-acetylglucosamine-6-sulfatase antibody, zgc:114066 antibody, gns antibody, wu:fi20h10 antibody, zgc:55370 antibody, glucosamine (N-acetyl)-6-sulfatase antibody, glucosamine (N-acetyl)-6-sulfatase S homeolog antibody, glucosamine (N-acetyl)-6-sulfatase a antibody, N-acetylglucosamine-6-sulfatase antibody, glucosamine (N-acetyl)-6-sulfatase (Sanfilippo disease IIID), b antibody, GNS antibody, Gns antibody, gns.S antibody, gns antibody, gnsa antibody, CpipJ_CPIJ000745 antibody, Sros_7372 antibody, VDBG_04409 antibody, Halhy_3165 antibody, gnsb antibody
    Background
    GNS is a lysosomal enzyme found in all cells. It is involved in the catabolism of heparin, heparin sulphate, and keratan sulphate. Deficiency of this enzyme results in the accumulation of undegraded substrate and the lysosomal storage disorder ucopolysaccharidosis type IIID (Sanfilippo D syndrome). Mucopolysaccharidosis type IIID is the least common of the four subtypes of Sanfilippo syndrome.The product of this gene is a lysosomal enzyme found in all cells. It is involved in the catabolism of heparin, heparan sulphate, and keratan sulphate. Deficiency of this enzyme results in the accumulation of undegraded substrate and the lysosomal storage disorder mucopolysaccharidosis type IIID (Sanfilippo D syndrome). Mucopolysaccharidosis type IIID is the least common of the four subtypes of Sanfilippo syndrome.
    Alias Symbols: G6S, MGC21274
    Protein Interaction Partner: LDHAL6B, BCCIP, UBFD1, CNDP2, SCLY, C11orf58, GDA, KYNU, RPS6KA1, PEPD, MVD, GLS, GLA, GBP2, G6PD, EIF5A, CASP7, CAPN1, FBXO6, UBC,
    Protein Size: 552
    Molecular Weight
    62 kDa
    Gene ID
    2799
    NCBI Accession
    NM_002076, NP_002067
    UniProt
    P15586
    Pathways
    Glycosaminoglycan Metabolic Process
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